Dovitinib lactate

• Catalog number
  B1615-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  Dovitinib lactate; TKI258; CHIR258; Dovitinib; TKI 258; CHIR 258; TKI-258; CHIR-258; 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; multitargeted receptor tyrosine kinase inhibitor
• Description
  Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays.
• CAS Number
  915769-50-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₉FN₆O₅
• Molecular Weight
  500.53
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A multitargeted RTK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD16038433
• PubChem CID
  16738710
• PubChem CID Link
• SMILES
  CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3.O
• InChi
  1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-
• InChi Key
  NOGSKCDVWBOZAQ-DJOSVPKASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Dovitinib   lactate  
• Short name
  Dovitinib lactate
• Alternative name
  Dovitinib lactate

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