MDC/CCL22, murine recombinant
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Catalog number7169-50
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PricePlease ask
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Size50 ug
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SynonymsMacrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1
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Alternative_namesMacrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1
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DescriptionChemoattracts monocytes, dendritic cells and NK cells
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RecombinantYes
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SourceE. Coli
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Purity by SDS PAGE≥98%
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AssaySDS-PAGE
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Endotoxin Level< 0.1 ng/ug of protein (
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Activity Specifications test methodDetermined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml.
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Biological activityDetermined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml.
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Molecular Weight7.8 kDa
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Storage Temp-20°C
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ShippingGel Pack
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Shelf Life12 months
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AppearanceLyophilized powder
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Physical form descriptionSterile filtered through a 0.2 micron filter. Lyophilized with no additives.
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Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Background InformationMDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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Amino acid sequenceGPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolADAM11, CCL22, ADAM28, TNFAIP8
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Short nameMDC/CCL22, murine recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameMDC/chemokine (C-C motif) ligand 22, murine Rec.
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Alternative techniquerec
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Alternative to gene targetchemokine (C-C motif) ligand 22, ABCD-1 and DC/B-CK and MDC and SCYA22 and STCP-1, CCL22 and IDBG-33170 and ENSG00000102962 and 6367, chemokine activity, Extracellular, Ccl22 and IDBG-182591 and ENSMUSG00000031779 and 20299, CCL22 and IDBG-632465 and ENSBTAG00000017718 and 616996
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Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase domain 11
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Synonyms gene
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Synonyms gene name
- a disintegrin and metalloproteinase domain 11
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-11-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidase domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine ligand 22
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Synonyms gene
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Synonyms gene name
- small inducible cytokine subfamily A (Cys-Cys), member 22
- chemokine (C-C motif) ligand 22
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-08-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Chemokine ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase domain 28
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Synonyms gene name
- a disintegrin and metalloproteinase domain 28
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-07-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidase domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTNF alpha induced protein 8
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Synonyms gene name
- tumor necrosis factor, alpha-induced protein 8
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-02-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data