ROR2 Antibody (NT)
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Catalog number6700-100
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PricePlease ask
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Size100 μl
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Antibody TargetROR2
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Target Alternative NameROR2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2
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Antibody TypePolyclonal
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Species ReactivitiesHuman
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Immunogen SequenceThis ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.
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AccessionQ01974
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Gene IdROR2
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AppearanceColorless liquid
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FormLiquid
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Formulation100 µl of antibody in PBS with 0.09% (W/V) sodium azide
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PurificationThis antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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ApplicationWestern blot, Immunohistochemistry, FACS
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Positive ControlWestern Blot: 293 cell lysate, IHC: Paraffin embedded human kidney carcinoma, FACS: NCI-H292
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Application And UsagesWestern blot: 1:1000, IHC: 1:10 to 1:50, FACS: 1:10 to 1:50
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DescriptionROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 may play differential roles during the development of the nervous system. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1 or the autosomal recessive skeletal disorder, Robinow syndrome.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedVerified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedVerified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolROR2, RORA
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Short nameROR2 Antibody (NT)
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameROR2 (antibody to-) (NT)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namereceptor tyrosine kinase like orphan receptor 2
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Synonyms gene
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Synonyms gene name
- receptor tyrosine kinase-like orphan receptor 2
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GenBank acession
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Locus
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Discovery year2000-02-29
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- I-set domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRAR related orphan receptor A
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Synonyms gene name
- RAR-related orphan receptor A
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-04-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RAR related orphan receptors
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data