Cyclin D1 Antibody

• Catalog number
  GEN438067
• Price
  Please ask
• Size
  100ug

• Also known as
  Cyclin D1
• Other names
  G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; BCL-1 oncogene; PRAD1 oncogene; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  CCND1
• Gene name synonims
  N/A
• Other gene names
  CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2a, kappa
• Clone
  SPM587
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens), Monkey, Mouse (Mus musculus), Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  ELISA, Biological Function Blockade, Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistology
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cyclin  
• Gene symbol
  CCND1, CCNDBP1
• Short name
  Cyclin D1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Anti-Cyclin D1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1582
• Gene
  CCND1
• Long gene name
  cyclin D1
• Synonyms gene
  • BCL1
  • D11S287E
  • PRAD1
• Synonyms gene name
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1)
• Synonyms
  • U21B31
• Synonyms name
  • parathyroid adenomatosis 1
  • B-cell CLL/lymphoma 1
  • G1/S-specific cyclin D1
• GenBank acession
  • Z23022
• Locus
  11q13.3
• Discovery year
  1991-06-06
• Entrez gene record
  595
• Pubmed identfication
  • 1826542
  • 1833066
• RefSeq identity
  • NM_053056
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000167877
• Locus Specific Databases
  • LRG_990

Gene info

• Identity
  HGNC:1587
• Gene
  CCNDBP1
• Long gene name
  cyclin D1 binding protein 1
• Synonyms gene name
  • cyclin D-type binding-protein 1
• Synonyms
  • DIP1
  • GCIP
  • HHM
• Synonyms name
  • D-type cyclin-interacting protein 1
  • MAID protein
  • grap2 and cyclin D interacting protein
• GenBank acession
  • AF082569
• Locus
  15q15.2
• Discovery year
  1998-10-02
• Entrez gene record
  23582
• Pubmed identfication
  • 10801854
• RefSeq identity
  • NM_012142
• VEGA ID
  OTTHUMG00000130703

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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