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LDN193189 for cell activation

LDN193189 for cell activation is available 2 times from Biovision labs

1995-25 | LDN193189 for cell activation size: 25 mg | 799.46 USD

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1995-5 | LDN193189 for cell activation size: 5 mg | 275.28 USD

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Other name 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine, hydrochloride; DM-3189
Supplied with N/A
Description Cell-permeable. LDN193189 is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189 has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.
Category Biochemicals
Molecular formula C₂₅H₂₂N₆.HCl
Is it cell-permeable? Yes
Molecular weight 442.94
Storage condition -20°C
Shipping condition gel pack
Purification ≥97% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 1062368-24-4 (free base)
Storage instructions Protect from light and moisture
Maximum time for storage 24months
Physical appearance Yellow solid
Reconstitute instructions DMSO (10 mM)
Additional description For cells, cell lines and tissues in culture till half confluency.
Short name LDN193189 for activation
Technique activation
Alternative name LDN193189 to measure cellular activation
Tissue cell
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