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K11-linked Tri-Ubiquitin

K11-linked Tri-Ubiquitin is available 1 time from Biovision labs

6422-50 | K11-linked Tri-Ubiquitin size: 50 ug | 356.19 USD

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Synonyms K11-linked Tri-Ubiquitin
Description Substrate for defined length polyubiquitination
Purity by SDS-PAGE ≥95%
Assay Western Blot
Molecular Weight 25.656 kDa (Band migrates faster on gels)
Storage Temp. -80°C
Shipping Dry ice
Shelf Life 12 months
Concentration 2.5 mg/ml
Appearance Liquid
Physical form description 2.5 mg/ml in 20 mM Tris-HCl, pH 7.5, 0.15 M NaCl and 1 mM EDTA.
Background Information Increasingly, researchers are focusing on the role poly-ubiquitin chains linked through K11. This post-translational modification has been linked to the ERAD cycle as a signal, similar to K48 linkage, for proteasomal degradation. More recently, K11 linkage appears to play an important role in cell cycle signaling, as it is associated with the anaphase promoting complex (APC) of ubiquitination machinery. These tri-ubiquitin chains are generated from the enzymatic linkage (UBE2S) of wild-type ubiquitin through lysine 11 and purified to >95% homogeneity by ion exchange chromatography.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Gene targetK11-linked Tri-Ubiquitin
Short name K11-linked Tri-Ubiquitin
Alternative name K11-linked Tri-Ubiquitin
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