Sphingomyelin Synthase 1 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-4216R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  Sphingomyelin Synthase 1 Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-Sphingomyelin Synthase 1 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Sphingomyelin Synthase 1
• Specificity
  This is a highly specific antibody against Sphingomyelin Synthase 1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  50-100/419
• Subcellular location
  Intracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1
• Gene ID Number
  259230
• Swiss Prot
  Q86VZ5
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  MOB; MOB1; SMS1; TMEM23; hmob33; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23; SGMS1
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Sphingomyelin Synthase 1 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  Sphingomyelin   Synthase  
• Gene symbol
  SGMS1
• Short name
  Anti-Sphingomyelin Synthase 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  Sphingomyelin Synthase 1 Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:29799
• Gene
  SGMS1
• Long gene name
  sphingomyelin synthase 1
• Synonyms gene
  • TMEM23
• Synonyms gene name
  • transmembrane protein 23
• Synonyms
  • MOB
  • MGC17342
  • SMS1
• Synonyms name
  • phosphatidylcholine:ceramide cholinephosphotransferase 1
• GenBank acession
  • AY280959
• Locus
  10q11.23
• Discovery year
  2004-03-23
• Entrez gene record
  259230
• Pubmed identfication
  • 11841947
  • 14976195
• RefSeq identity
  • NM_147156
• Classification
  • Sterile alpha motif domain containing
• VEGA ID
  OTTHUMG00000018231

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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