PAC-1

Alternative_name

2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid
Description

Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an IC₅₀ value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had IC₅₀ values of 3.2-8.5 µM.
CAS Number

315183-21-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₈N₄O₂
Molecular Weight

392.49
Cell Permeable

Yes
Purity

≥95% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A pro-caspase-3 activator
Storage Condition

+4°C
Shipping Condition

RT
Shelf Life

24 months
MDL Number

MFCD03302441
PubChem CID

6851947
PubChem CID Link
SMILES

C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O
InChi

InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27- 14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2, (H,25,28)/b21-16-
InChi Key

XSGXRYNZNGUGEJ-PGMHBOJBSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

PAC-1
Gene symbol

DUSP2, PACC1, ADCYAP1R1, GLYR1, PSMG1, KLF6, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1
Short name

PAC-1
Alternative name

PAC-1

Identity

HGNC:25593
Gene

PACC1
Long gene name

proton activated chloride channel 1
Synonyms gene
- C1orf75
- TMEM206
Synonyms gene name
- chromosome 1 open reading frame 75
- transmembrane protein 206
Synonyms
- FLJ10874
- PAC
GenBank acession
- AK024066
Locus

1q32.3
Discovery year

2005-05-19
Entrez gene record

55248
Pubmed identfication
- 30417481
- 31318332
RefSeq identity
- NM_018252
VEGA ID

OTTHUMG00000036751

Identity

HGNC:242
Gene

ADCYAP1R1
Long gene name

ADCYAP receptor type I
Synonyms gene name
- adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Synonyms
- PAC1
- PACAPR
- PAC1R
Synonyms name
- PACAP receptor 1
- pituitary adenylate cyclase-activating polypeptide type 1 receptor
Locus

7p14.3
Discovery year

1994-05-18
Entrez gene record

117
Pubmed identfication
- 7902709
RefSeq identity
- NM_001118
Classification
- Vasoactive intestinal peptide family receptors
VEGA ID

OTTHUMG00000023884

Identity

HGNC:3043
Gene

PSMG1
Long gene name

proteasome assembly chaperone 1
Synonyms gene
- DSCR2
Synonyms gene name
- Down syndrome critical region gene 2
- proteasome (prosome, macropain) assembly chaperone 1
Synonyms
- c21-LRP
- LRPC21
- PAC1
GenBank acession
- AJ006291
Locus

21q22.2
Discovery year

1999-09-17
Entrez gene record

8624
Pubmed identfication
- 10872820
- 17189198
RefSeq identity
- NM_003720
VEGA ID

OTTHUMG00000066034

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325