Human CellExp™ IL-12 R beta 1 / CD212, Fc Tag, Human Recombinant

• Catalog number
  P1458-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
• Alternative_names
  IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
• Description
  Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
• Recombinant
  False
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >95%
• Assay
  SDS-PAGE
• Endotoxin Level
  Less than 1.0 EU per ug by the LAL method.
• Molecular Weight
  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized
• Reconstitution Instructions
  Reconstitute in sterile deionized water to the desired protein concentration.
• Background Information
  The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
• Amino acid sequence
  Cys 24 - Glu 540
• Handling
  Centrifuge the vial prior to opening.
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   IL-12   beta   CD212   Tag  
• Gene symbol
  IFNLR1, IL12RB1, PIRC55, PIRC57, PIRC53, PIRC54, PIRC56, SNORD115-12, SNORD114-12
• Short name
  CellExp™ IL-12 R beta 1 / CD212, Fc Tag, Recombinant
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ Interleukin-12 R b 1 / CD212, fragment c detection labelled, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:18584
• Gene
  IFNLR1
• Long gene name
  interferon lambda receptor 1
• Synonyms gene
  • IL28RA
• Synonyms gene name
  • interleukin 28 receptor, alpha
  • interleukin 28 receptor, alpha (interferon, lambda receptor)
  • interferon, lambda receptor 1
• Synonyms
  • CRF2/12
  • IFNLR
  • IL-28R1
• GenBank acession
  • AY129153
• Locus
  1p36.11
• Discovery year
  2002-12-02
• Entrez gene record
  163702
• RefSeq identity
  • NM_170743
• Classification
  • Interferon receptors
• VEGA ID
  OTTHUMG00000003036

Gene info

• Identity
  HGNC:5971
• Gene
  IL12RB1
• Long gene name
  interleukin 12 receptor subunit beta 1
• Synonyms gene
  • IL12RB
• Synonyms gene name
  • interleukin 12 receptor, beta 1
• Synonyms
  • CD212
• GenBank acession
  • U03187
• Locus
  19p13.11
• Discovery year
  1995-09-14
• Entrez gene record
  3594
• Pubmed identfication
  • 9284929
• Classification
  • Fibronectin type III domain containing
  • CD molecules
  • Interleukin receptors
• VEGA ID
  OTTHUMG00000183417
• Locus Specific Databases
  • IL12RB1base: Mutation registry for Interleukin-12 receptor ß1 deficiency
  • LRG_72

Gene info

• Identity
  HGNC:37559
• Gene
  PIRC55
• Long gene name
  piwi-interacting RNA cluster 55
• Locus
  12
• Discovery year
  2009-11-05
• Entrez gene record
  100313792
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37561
• Gene
  PIRC57
• Long gene name
  piwi-interacting RNA cluster 57
• Locus
  12
• Discovery year
  2009-11-05
• Entrez gene record
  100313930
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37557
• Gene
  PIRC53
• Long gene name
  piwi-interacting RNA cluster 53
• Locus
  12
• Discovery year
  2009-11-05
• Entrez gene record
  100313861
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37558
• Gene
  PIRC54
• Long gene name
  piwi-interacting RNA cluster 54
• Locus
  12
• Discovery year
  2009-11-05
• Entrez gene record
  100313815
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37560
• Gene
  PIRC56
• Long gene name
  piwi-interacting RNA cluster 56
• Locus
  12
• Discovery year
  2009-11-05
• Entrez gene record
  100313862
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33031
• Gene
  SNORD115-12
• Long gene name
  small nucleolar RNA, C/D box 115-12
• Synonyms
  • HBII-52-12
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033449
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003304.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33000
• Gene
  SNORD114-12
• Long gene name
  small nucleolar RNA, C/D box 114-12
• Synonyms
  • 14q(II-12)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767590
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003205.1
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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