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anti PCAF Antibody

anti PCAF Antibody is available 4 times from Biovision labs

6675-30T | anti-PCAF Antibody size: PCAF Antibody | 174.28 USD

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6675-100 | anti-PCAF Antibody size: PCAF Antibody | 400.73 USD

Catalog number 6675-100
Supplier Biovision
Price 400.73 USD
Size PCAF Antibody
Background information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. P300/CBP-associated factor (PCAF) is a transcriptional coactivator that works both as a histone lysine acetyltransferase, through its HAT domain, and as an acetyl-lysine reader through its conserved bromodomain located directly C-terminal to the HAT domain. The PCAF bromodomain binds acetylated histone H3 and H4 as well as non-histone targets. Bromodomain binding is dictated by the position of the acetylated lysine as well as interactions with specific residues flanking the acetyl-lysine. PCAF also specifically binds the HIV viral protein Tat on acetylated K50 to regulate its transactivating activity and help induce chromatin remodeling of proviral genes, thereby promoting transcription of viral proteins.
This antibody reacts with: Human
Immunogene sequence: Recombinant human PCAF protein (Cat # 1137)
Concentration of antibody: 0.5 mg/ml
Formulation of this antibody: 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Purification method: Affinity Purified Antibody
This antibody has been succesfully tested for use in following methods: Western blot
Recommended usage: Western blot: 1-4 µg/ml.
Gene targetPCAF
Short name anti-PCAF Antibody
Alternative name antibody to-PCAF (Antibody to)
1. Gene info
Identity 4201
Gene KAT2A
Long gene name lysine acetyltransferase 2A
Synonyms gene
  • GCN5L2
Synonyms gene name
  • GCN5 general control of amino-acid synthesis 5-like 2 (yeast)
  • K(lysine) acetyltransferase 2A
Synonyms
  • GCN5
  • PCAF-b
GenBank acession
  • AF029777
Locus 17q21.2
Discovery year 1996-12-17
Entrez gene record 2648
Pubmed identfication
  • 8552087
RefSeq identity
  • NM_021078
Classification
  • Lysine acetyltransferases
  • SAGA complex
  • ATAC complex
  • GCN5 related N-acetyltransferases
  • Bromodomain containing
Havana BLAST/BLAT OTTHUMG00000133504
2. Gene info
Identity 17304
Gene TAF5L
Long gene name TATA-box binding protein associated factor 5 like
Synonyms gene name
  • TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kD
  • TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
Synonyms
  • PAF65B
Synonyms name
  • PCAF associated factor 65 beta
GenBank acession
  • AF069736
Locus 1q42.13
Discovery year 2001-12-04
Entrez gene record 27097
Pubmed identfication
  • 9674425
  • 11124703
RefSeq identity
  • NM_014409
Classification
  • WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000039463
Product images
    #0#.jpegPCAF Antibody

6763-100 | anti-PCAF Antibody (CT) size: PCAF Antibody (CT) | 374.65 USD

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6762-100 | anti-PCAF Antibody (NT) size: PCAF Antibody (NT) | 374.65 USD

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Target of this antibody: PCAF
Alternative names of antibody target: KAT2B; PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
Form of antibody: Liquid
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Technique Antibody, anti
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anti-PCAF Antibody | Technique alternative | 01012194093
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  • PCAF
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