Peroxiredoxin 2 Antibody

• Catalog number
  bs-8300R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Peroxiredoxin 2 Primary Polyclonal Antibody
• Also known as
  Peroxiredoxin 2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Peroxiredoxin 2
• Specificity
  This is a highly specific antibody against Peroxiredoxin 2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
• Gene ID number
  7001
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MGC4104; Natural killer cell enhancing factor B; Natural killer cell-enhancing factor B; Natural Killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin-2; PRDX 2; PRDX2; PRDX2_HUMAN; PRP; PRX2; PRXII; TDPX1; Thiol Specic Antioxidant 1; Thiol specic antioxidant protein; Thiol-specic antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin Peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Peroxiredoxin  
• Gene symbol
  PRDX2P2, PRDX2P4, PRDX4P2
• Short name
  Anti-Peroxiredoxin 2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Peroxiredoxin 2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:44967
• Gene
  PRDX2P2
• Long gene name
  peroxiredoxin 2 pseudogene 2
• Locus
  10p11.21
• Discovery year
  2012-12-20
• Entrez gene record
  646218
• RefSeq identity
  • NG_022167
• VEGA ID
  OTTHUMG00000017949

Gene info

• Identity
  HGNC:44969
• Gene
  PRDX2P4
• Long gene name
  peroxiredoxin 2 pseudogene 4
• Locus
  6q16.3
• Discovery year
  2012-12-20
• Entrez gene record
  442239
• RefSeq identity
  • NG_022363
• VEGA ID
  OTTHUMG00000015274

Gene info

• Identity
  HGNC:43599
• Gene
  PRDX4P2
• Long gene name
  peroxiredoxin 4 pseudogene 2
• Locus
  5p13.2
• Discovery year
  2011-11-23
• Entrez gene record
  100418942
• RefSeq identity
  • NG_024668

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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