Anti- STAT1 Antibody

• Catalog number
  A1215-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  STAT1
• Target Alternative Name
  Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human STAT1
• Accession
  P42224
• Gene Id
  6772
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
• Purification
  Affinity purified
• Application
  WB
• Positive Control
  WB; HEK293T, RAW264.7, H9C2 cell lysate
• Application And Usages
  WB; 1:500 – 1:2000
• Description
  Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  STAT1  
• Gene symbol
  STAT1
• Short name
  Anti- STAT1 Antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  antibody to- signal transducer and activator on transcription 1, 91kDa (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  signal transducer and activator of transcription 1, 91kDa, CANDF7 and IMD31A and IMD31B and IMD31C and ISGF-3 and STAT91, STAT1 and IDBG-77617 and ENSG00000115415 and 6772, sequence-specific DNA binding, nuclei, Stat1 and IDBG-153162 and ENSMUSG00000026104 and 20846, STAT1 and IDBG-642654 and ENSBTAG00000007867 and 510814,515988

Gene info

• Identity
  HGNC:11362
• Gene
  STAT1
• Long gene name
  signal transducer and activator of transcription 1
• Synonyms gene name
  • signal transducer and activator of transcription 1, 91kD
  • signal transducer and activator of transcription 1, 91kDa
• Synonyms
  • STAT91
  • ISGF-3
• Synonyms name
  • transcription factor ISGF-3 components p91/p84
• Locus
  2q32.2
• Discovery year
  1995-11-08
• Entrez gene record
  6772
• Pubmed identfication
  • 7885841
• RefSeq identity
  • NM_007315
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000132699
• Locus Specific Databases
  • STAT1base: Mutation registry for STAT1 deficiency
  • LRG_111

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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