TGFBR1 Antibody

• Catalog number
  F52206-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TGFBR1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the TGFBR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TGFBR1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P36897
• Purity
  Antigen affinity
• Description
  Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
• Immunogen
  A portion of amino acids 145-172 from the human protein was used as the immunogen for this TGFBR1 antibody.
• Storage
  Aliquot the TGFBR1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TGFBR1  
• Gene symbol
  TGFBR1
• Short name
  Anti-TGFBR1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to TGFBR1
• Alternative technique
  antibodies
• Alternative to gene target
  transforming growth factor, beta receptor 1, AAT5 and ACVRLK4 and ALK-5 and ALK5 and ESS1 and LDS1 and LDS1A and LDS2A and MSSE and SKR4 and TGFR-1, TGFBR1 and IDBG-78488 and ENSG00000106799 and 7046, transforming growth factor beta receptor activity, Cell surfaces, Tgfbr1 and IDBG-146050 and ENSMUSG00000007613 and 21812, TGFBR1 and IDBG-634152 and ENSBTAG00000018035 and 282382

Gene info

• Identity
  HGNC:11772
• Gene
  TGFBR1
• Long gene name
  transforming growth factor beta receptor 1
• Synonyms gene
  • MSSE
  • ESS1
• Synonyms gene name
  • multiple self-healing squamous epithelioma
  • transforming growth factor beta receptor I
• Synonyms
  • ALK-5
  • ACVRLK4
  • ALK5
  • TBRI
  • TBR-i
• Synonyms name
  • activin A receptor type II-like kinase, 53kDa
• Locus
  9q22.33
• Discovery year
  1993-09-30
• Entrez gene record
  7046
• Pubmed identfication
  • 1319842
  • 8530052
  • 21358634
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000020353
• Locus Specific Databases
  • LOVD - Center for Medical Genetics, Ghent, Belgium

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products