IL-21, murine recombinant

• Catalog number
  4183-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  IL-21, Interleukin 21
• Alternative_names
  Za11, IL-21, Interleukin-21
• Description
  A cytokine regulating cells of the immune system
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  The bioactivity is determined by a dose-dependent proliferation of lymphocytes co-stimulated with anti-CD3ɛ and is typically 2-50 ng/ml.
• Molecular Weight
  15.095 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 20 mM NaHCO₃, pH 8.5
• Reconstitution Instructions
  When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H₂O to a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
• Background Information
  Mouse Interleukin-21 (m-IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which also includes IL-2, IL-4, IL-7, IL-9, and IL-13. Its private receptor, IL-21R, is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathways upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, the differentiation, and the effector functions of B, T, natural killer, and dendritic cells. Recombinant mouse IL-21, produced in E.coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a total molecular mass of 15,095 Daltons.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL-21   murine  
• Gene symbol
  IL21, IL17C, IL22, IL21-AS1, PIRC105, HTOR, SNORD115-21, SNORD114-21
• Short name
  IL-21, murine recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  Interleukin-21, murine Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6005
• Gene
  IL21
• Long gene name
  interleukin 21
• Synonyms
  • Za11
  • IL-21
• GenBank acession
  • AF254069
• Locus
  4q27
• Discovery year
  2000-03-29
• Entrez gene record
  59067
• Pubmed identfication
  • 11081504
  • 17947662
• RefSeq identity
  • NM_021803
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000133073
• Locus Specific Databases
  • LRG_1263

Gene info

• Identity
  HGNC:5983
• Gene
  IL17C
• Long gene name
  interleukin 17C
• Synonyms
  • IL-17C
  • CX2
  • IL-21
  • MGC126884
  • MGC138401
• GenBank acession
  • AF152099
• Locus
  16q24.2
• Discovery year
  2000-01-20
• Entrez gene record
  27189
• Pubmed identfication
  • 10639155
• RefSeq identity
  • NM_013278
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000173241

Gene info

• Identity
  HGNC:14900
• Gene
  IL22
• Long gene name
  interleukin 22
• Synonyms
  • ILTIF
  • IL-21
  • zcyto18
  • IL-TIF
  • IL-D110
  • TIFa
  • TIFIL-23
  • IL-22
  • MGC79382
  • MGC79384
• Synonyms name
  • IL-10-related T-cell-derived inducible factor
• GenBank acession
  • AF279437
• Locus
  12q15
• Discovery year
  2001-03-12
• Entrez gene record
  50616
• Pubmed identfication
  • 10954742
  • 10875937
• RefSeq identity
  • NM_020525
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000169119
• Locus Specific Databases
  • LRG_1248

Gene info

• Identity
  HGNC:40299
• Gene
  IL21-AS1
• Long gene name
  IL21 antisense RNA 1
• Synonyms gene name
  • IL21 antisense RNA 1 (non-protein coding)
• GenBank acession
  • BC045668
• Locus
  4q27
• Discovery year
  2012-08-09
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150127

Gene info

• Identity
  HGNC:37609
• Gene
  PIRC105
• Long gene name
  piwi-interacting RNA cluster 105
• Locus
  21
• Discovery year
  2009-11-05
• Entrez gene record
  100313936
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:5285
• Gene
  HTOR
• Long gene name
  5-hydroxytryptamine (serotonin) oxygenase regulator
• Locus
  21
• Discovery year
  2001-06-22
• Entrez gene record
  3349
• Pubmed identfication
  • 93675

Gene info

• Identity
  HGNC:33040
• Gene
  SNORD115-21
• Long gene name
  small nucleolar RNA, C/D box 115-21
• Synonyms
  • HBII-52-21
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033603
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003313.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33009
• Gene
  SNORD114-21
• Long gene name
  small nucleolar RNA, C/D box 114-21
• Synonyms
  • 14q(II-21)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767599
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003214.1
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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