Recombinant Human ADAMTS5, (Aggrecanase2),truncated, His-tagged (Recombinant Protein)

  • Catalog number
    30 400 502
  • Price
    Please ask
  • Size
    5 µg/ 50 µl
  • Protein type
    Recombinant
  • Protein subtype
    EC 3.4.24.14
  • Protein family
    ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.
  • Protein description
    ADAMTS5 cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
  • Research area interests
    Diseases associated with ADAMTS5 include Osteoarthritis and Bone Inflammation Disease. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification
  • Package form
    liquid
  • Tested applications
    Degradation of extracellular matrix proteoglycans; screening and characterization of inhibitors; Standard in enzymatic and immunological assays
  • Other names
    A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2); ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5
  • Peptide sequence
    D625-930
  • Available target modification
    No
  • Expression system
    Insect Cell
  • Product Subtype
    protein fragment
  • Active form
    Yes
  • Tag
    His-tagged
  • Contents
    150 mM NaCl, 5 mM CaCl2, 50 mM imidazol, 50 mM Tris-HCl, pH 7.5, 0.05 % Brij-35 Detergent
  • Protein purity
    > 50 %
  • Molecular weight
    50 kDa
  • UniProt number
    Q9UNA0
  • Gene number
    11096
  • Abbreviation
    ADAMTS5 (partial)
  • Full name
    ADAM metallopeptidase with thrombospondin type 1 motif 5 (partial)
  • Other desciption
    Recombinant human ADAMTS5 Δ625-930 is produced with the baculovirus expression system and enriched from insect cell culture supernatants
  • Purification
    Mentioned in the data sheet
  • PubMed citations
    See the data sheet
  • Warnings
    For Research Use only.
  • Shipping conditions
    dry ice
  • Storage condition
    Store at -70°C
  • Technical datasheet
    Contact us to receive the datasheet
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    ADAMTS5
  • Short name
    Recombinant ADAMTS5, (Aggrecanase2),truncated, His-tagged (Recombinant Protein)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Label
    his-tagged
  • Species
    Homo sapiens, Humans
  • Alternative name
    Rec. H. sapiens ADAM metallopeptidase including thrombospondin classification 1 motif, 5, (Aggrecanase2),truncated, histidine-tagged (Rec. Protein)
  • Alternative technique
    rec
  • Alternative to gene target
    ADAM metallopeptidase with thrombospondin type 1 motif, 5, ADAM-TS 11 and ADAM-TS 5 and ADAM-TS5 and ADAMTS-11 and ADAMTS-5 and ADAMTS11 and ADMP-2, ADAMTS5 and IDBG-1207 and ENSG00000154736 and 11096, zinc ion binding, Extracellular, Adamts5 and IDBG-173252 and ENSMUSG00000022894 and 23794, ADAMTS5 and IDBG-630284 and ENSBTAG00000000648 and 286805
Gene info
  • Identity
  • Gene
  • Long gene name
    ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Synonyms gene name
    • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1999-08-23
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • ADAM metallopeptidases with thrombospondin type 1 motif
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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