INCB-024360
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Catalog number9477-5
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PricePlease ask
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Size5 mg
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Alternative_name(E)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide); Epacadostat; INCB24360
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DescriptionINCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities
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CAS Number1204669-58-8
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Structure AvailableYes
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Molecular FormulaC₁₁H₁₃BrFN₇O₄S
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Molecular Weight438.23
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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PubChem CID44608567
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SMILESC1=CC(=C(C=C1N/C(=C\2/C(=NON2)NCCNS(=O)(=O)N)/N=O)Br)F
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InChiInChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16-17,19H,3-4H2,(H,15,20)(H2,14,22,23)/b11-9+
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InChi KeyYPBKTZBXSBLTDK-PKNBQFBNSA-N
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MSDS AvailableYes
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Gene target
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Short nameINCB-024360
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Alternative nameINCB-024360
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