Anti-CNG4/GARP (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-12093R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  CNG4/GARP
• Specificity
  This antibody reacts specifically with CNG4/GARP
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Extracellular
• Antigen Source
  KLH conjugated synthetic peptide derived from human CNG4
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits (1,2). The alpha subunits consist of CNG1-3 and form functional cation channels by themselves (1,2). The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels (1,2). CNG channels are essential components of olfactory and visual transduction (1,2). In olfactory neurons, CNG2, CNG4.3 and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in response to cAMP (1-3). In rod photoreceptors, CNG1 and CNG4.1 combine to form Ca ion permeable channels, which give rise to a current in response to cGMP (1-3). CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel (2,3). CNG channels have been implicated in other areas (4-6). CNG1 is also expressed in medium-sized and small-sized arteries, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions (4). CNG1, CNG4.1 and CNG4.2 have been detected in the rat pineal gland (5). CNG2, CNG4.3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone (6).
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  CNCG2; CNCG3L; CNCG4; CNG 4; CNG-4; CNG channel 4; CNG channel beta 1; CNG4; CNGB 1; CNGB1; CNGB1B; Cyclic nucleotide gated cation channel 4; Cyclic nucleotide gated cation channel; Cyclic nucleotide gated cation channel beta 1; Cyclic nucleotide gated cation channel gamma; Cyclic nucleotide gated cation channel modulatory subunit; Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like; Cyclic nucleotide gated channel beta 1; GAR1; Glutamic acid rich protein; RCNC2; RCNCb; RCNCbeta; RP45; CNGB1_HUMAN.
• Also known as
  CNG4/GARP Polyclonal Antibody
• Other name
  Anti-CNG4/GARP Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  CNG4/GARP  
• Gene symbol
  SH3BGR, LRRC32, CNGB1
• Short name
  Anti-CNG4/GARP
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  CNG4/GARP Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:10822
• Gene
  SH3BGR
• Long gene name
  SH3 domain binding glutamate rich protein
• Synonyms gene name
  • SH3 domain binding glutamic acid-rich protein
  • SH3 domain binding glutamate-rich protein
• Synonyms
  • 21-GARP
• Synonyms name
  • 21-glutamic acid-rich protein
• Locus
  21q22.2
• Discovery year
  1996-10-11
• Entrez gene record
  6450
• Pubmed identfication
  • 9050928
• RefSeq identity
  • NM_007341
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000074113

Gene info

• Identity
  HGNC:4161
• Gene
  LRRC32
• Long gene name
  leucine rich repeat containing 32
• Synonyms gene
  • D11S833E
  • GARP
• Synonyms gene name
  • glycoprotein A repetitions predominant
• GenBank acession
  • Z24680
• Locus
  11q13.5
• Discovery year
  1994-12-15
• Entrez gene record
  2615
• Pubmed identfication
  • 8180135
  • 1543912
• RefSeq identity
  • NM_005512
• VEGA ID
  OTTHUMG00000133687

Gene info

• Identity
  HGNC:2151
• Gene
  CNGB1
• Long gene name
  cyclic nucleotide gated channel subunit beta 1
• Synonyms gene
  • CNCG2
  • CNCG3L
• Synonyms gene name
  • cyclic nucleotide gated channel beta 1
• Synonyms
  • RCNC2
  • RCNCb
  • GARP
  • GAR1
  • CNGB1B
  • RP45
• Synonyms name
  • glutamic acid-rich protein
  • cyclic nucleotide-gated cation channel beta-1
• GenBank acession
  • AF042498
• Locus
  16q21
• Discovery year
  1994-12-20
• Entrez gene record
  1258
• Pubmed identfication
  • 8766832
  • 7590744
  • 16382102
• RefSeq identity
  • NM_001297
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000154810

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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