EZSolution™ GW2580

• Catalog number
  2549-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
• Description
  A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases.  GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.
• CAS Number
  870483-87-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₂N₄O₃
• Molecular Weight
  366.41
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Handling
  Protect from air and moisture
• Tag Line
  A cFMS kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• PubChem CID
  11617559
• PubChem CID Link
• SMILES
  COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
• InChi
  InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
• InChi Key
  MYQAUKPBNJWPIE-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  EZSolution™   GW2580  
• Short name
  EZSolution™ GW2580
• Alternative name
  EZSolution™ GW2580

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