Target of this antibody:
Alternative names of antibody target:
DNA repair protein XRCC3; X-ray repair cross-complementing protein 3
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
Clonality of antibody:
This antibody reacts with:
Human, Mouse, Rat
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human XRCC3
Form of antibody:
Formulation of this antibody:
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
This antibody has been succesfully tested for use in following methods:
WB, IH, IF/IC
WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
antibody to-Anti-X-ray repair complementing defective repair in Chinese hamster cells 3 (Antibody to)
Alternative to gene target
X-ray repair complementing defective repair in Chinese hamster cells 3, CMM6, XRCC3 and IDBG-22058 and ENSG00000126215 and 7517, crossover junction endodeoxyribonuclease activity, nuclei, Xrcc3 and IDBG-173748 and ENSMUSG00000021287 and 74335, XRCC3 and IDBG-635474 and ENSBTAG00000009966 and 768244