CCL14/HCC-1/HCC-3, human recombinant

• Catalog number
  4275-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1(1-74), NCC-2, Small-inducible cytokine A16
• Alternative_names
  C-C motif chemokine 14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1(1-74), NCC-2, Small-inducible cytokine A14, Cleaved into: HCC-1(3-74), HCC-1(4-74), HCC-1(9-74)
• Description
  Activator of monocytes
• Recombinant
  Yes
• Source
  Mammalian cell expression system
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Molecular Weight
  ~9.5 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from a 0.2 um filtered solution of 20 mM PB and 150 mM NaCl, pH 7.2.
• Reconstitution Instructions
  Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). This can further be diluted to other aqueous buffers.
• Background Information
  Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut. CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.
• Amino acid sequence
  Target protein is expressed with sequence (Thr20-Asn93) of Human hcc-1 (Uniprot #Q16627) fused with a polyhistidine tag at the C-terminus.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CCL14/HCC-1/HCC-3  
• Gene symbol
  CCL14, SARNP, SRRD, MRPS11, TTC23, RBMS1, FAM126A, CCL15, CCL16, CCL15-CCL14
• Short name
  CCL14/HCC-1/HCC-3, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  CCL14/HCC-1/HCC-3, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10612
• Gene
  CCL14
• Long gene name
  C-C motif chemokine ligand 14
• Synonyms gene
  • SCYA14
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 14
  • chemokine (C-C motif) ligand 14
• Synonyms
  • HCC-1
  • HCC-3
  • NCC-2
  • SCYL2
  • CKb1
  • MCIF
• GenBank acession
  • Z49270
• Locus
  17q12
• Discovery year
  1997-02-11
• Entrez gene record
  6358
• Pubmed identfication
  • 8661057
• RefSeq identity
  • NM_032962
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188403

Gene info

• Identity
  HGNC:24432
• Gene
  SARNP
• Long gene name
  SAP domain containing ribonucleoprotein
• Synonyms
  • THO1
  • Hcc-1
  • CIP29
• Synonyms name
  • hepatocellular carcinoma 1
  • cytokine induced protein 29 kDa
• GenBank acession
  • AJ409089
• Locus
  12q13.2
• Discovery year
  2009-04-22
• Entrez gene record
  84324
• Pubmed identfication
  • 11356193
  • 11922608
• RefSeq identity
  • NM_033082
• Classification
  • Transcription and export complex 1 subunits
• VEGA ID
  OTTHUMG00000170441

Gene info

• Identity
  HGNC:33910
• Gene
  SRRD
• Long gene name
  SRR1 domain containing
• Synonyms
  • HC/HCC
  • SRR1L
• Synonyms name
  • hepatocellular carcinoma complicating hemochromatosis
• GenBank acession
  • BC066962
• Locus
  22q12.1
• Discovery year
  2007-12-05
• Entrez gene record
  402055
• RefSeq identity
  • NM_001013694
• VEGA ID
  OTTHUMG00000150885

Gene info

• Identity
  HGNC:14050
• Gene
  MRPS11
• Long gene name
  mitochondrial ribosomal protein S11
• Synonyms
  • FLJ23406
  • HCC-2
  • FLJ22512
• Synonyms name
  • cervical cancer proto-oncogene 2
• GenBank acession
  • AB051349
• Locus
  15q25.3
• Discovery year
  2001-02-28
• Entrez gene record
  64963
• Pubmed identfication
  • 11402041
• RefSeq identity
  • NM_022839
• Classification
  • Mitochondrial ribosomal proteins
  • Small subunit mitochondrial ribosomal proteins
• VEGA ID
  OTTHUMG00000148678

Gene info

• Identity
  HGNC:25730
• Gene
  TTC23
• Long gene name
  tetratricopeptide repeat domain 23
• Synonyms
  • FLJ12572
  • HCC-8
• Locus
  15q26.3
• Discovery year
  2005-08-12
• Entrez gene record
  64927
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NM_022905
• Classification
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000147344

Gene info

• Identity
  HGNC:9907
• Gene
  RBMS1
• Long gene name
  RNA binding motif single stranded interacting protein 1
• Synonyms gene
  • C2orf12
• Synonyms gene name
  • chromosome 2 open reading frame 12
• Synonyms
  • SCR2
  • MSSP-1
  • MSSP-2
  • MSSP-3
  • YC1
  • HCC-4
  • DKFZp564H0764
• Synonyms name
  • suppressor of cdc 2 (cdc13) with RNA binding motif 2
  • c-myc gene single strand binding protein 2
• GenBank acession
  • D28482
• Locus
  2q24.2
• Discovery year
  1998-02-27
• Entrez gene record
  5937
• Pubmed identfication
  • 8041632
  • 8134115
  • 7838710
• RefSeq identity
  • NM_016836
• Classification
  • RNA binding motif containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000132031

Gene info

• Identity
  HGNC:24587
• Gene
  FAM126A
• Long gene name
  family with sequence similarity 126 member A
• Synonyms gene name
  • family with sequence similarity 126, member A
• Synonyms
  • DRCTNNB1A
  • HCC
  • HYCC1
  • hyccin
• Synonyms name
  • down regulated by Ctnnb1, a
• GenBank acession
  • BC018710
• Locus
  7p15.3
• Discovery year
  2006-09-06
• Entrez gene record
  84668
• Pubmed identfication
  • 29229838
  • 10910037
  • 16951682
  • 26571211
• RefSeq identity
  • NM_032581
• Classification
  • PI4KA lipid kinase complex
• VEGA ID
  OTTHUMG00000128435

Gene info

• Identity
  HGNC:10613
• Gene
  CCL15
• Long gene name
  C-C motif chemokine ligand 15
• Synonyms gene
  • SCYA15
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 15
  • chemokine (C-C motif) ligand 15
• Synonyms
  • HCC-2
  • NCC-3
  • SCYL3
  • MIP-5
  • Lkn-1
  • MIP-1d
  • HMRP-2B
• Synonyms name
  • leukotactin 1
  • CC chemokine 3
  • macrophage inflammatory protein 5
  • chemokine CC-2
  • MIP-1 delta
• GenBank acession
  • AF031587
• Locus
  17q12
• Discovery year
  1997-02-11
• Entrez gene record
  6359
• Pubmed identfication
  • 8661057
• RefSeq identity
  • NM_004167
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188406

Gene info

• Identity
  HGNC:10614
• Gene
  CCL16
• Long gene name
  C-C motif chemokine ligand 16
• Synonyms gene
  • SCYA16
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 16
  • chemokine (C-C motif) ligand 16
• Synonyms
  • NCC-4
  • SCYL4
  • LEC
  • HCC-4
  • LMC
  • LCC-1
  • CKb12
  • Mtn-1
• GenBank acession
  • AB007454
• Locus
  17q12
• Discovery year
  1997-02-11
• Entrez gene record
  6360
• Pubmed identfication
  • 8661057
• RefSeq identity
  • NM_004590
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188402

Gene info

• Identity
  HGNC:44436
• Gene
  CCL15-CCL14
• Long gene name
  CCL15-CCL14 readthrough (NMD candidate)
• Locus
  17q12
• Discovery year
  2012-10-08
• Entrez gene record
  348249
• VEGA ID
  OTTHUMG00000188405

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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