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Category
Primary Antibodies
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Long description
GRO beta is a member of the CXC, or chemokine class. It contains the ELR domain immediately preceding the first cysteine residue near the amino terminus. Other chemokines in this group include IL8, GRO alpha/beta/gamma, mouse KC, ENA78, GCP2, PBP/CTAPIII/beta TG/NAP2. These chemokines act primarily on neutrophils as chemoattractants and activators, including neutrophil degradation with release of myloperoxidase and other enzymes. GRO beta was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. GRO beta is an approximately 8 kDa polypeptide of 73 amino acids. The precursor form of GRO beta consists of 100 amino acids. To generate the mature GRO beta, the precursor cleaves its amino terminal 27 amino acids. GRO beta shows 60% amino acid homology to human GRO alpha and GRO gamma.
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Antibody come from
KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.
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Other description
Provided as solution in phosphate buffered saline, pH 7.3, with 1% BSA and 0.08% sodium azide. Protein A/G Chromatography
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti GRO beta antibody CXCL2 Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Rat
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
ELISA-Capture Antibody
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Antibody s suited for
Antibody can be used for Western blotting (0.5-1 µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
1. Horowitz, P.M., et al. (2004) Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J. Neurosci. 24(36):7895-902._x000B__x000B_2. Gamblin, T.C., et al. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. NatÕl. Acad. Sci. USA 100(17):10032-10037._x000B__x000B_3. Berry, R.W., et al. (2003) Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment. Biochemistry 42(27):8325-8331._x000B__x000B_4. Liu, F., et al. (2002) Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett. 530(1-3):209-214._x000B__x000B_5. Alonso, A.D., et al. (2001) Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. J. Biol. Chem. 276(41):37967-37973._x000B__x000B_6. Jenkins, S.M., et al. (2000) Modulation of tau phosphorylation and intracellular localization by cellular stress. Biochem. J. 345(Pt 2):263-270._x000B__x000B_7. Mandelkow, E. (1999) Alzheimer's disease. The tangled tale of tau. Nature 402(6762):588-589.
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Properties
If you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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French translation
anticorps
