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Stock availabilitIn Stock
In Stock
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CAS number
146535-11-7
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Description
PDGFR kinase inhibitor
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Molecular weight
266,3 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
Tyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline, 6,7-Dimethoxy-2-phenylquinoxaline
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C16H14N2O2
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Origin
Synthetic
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Purity pourcentage
≥98% (TLC)
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Soluble in
Soluble in DMSO or dichloromethane
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Physical appearance
Off-white to brownish solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
2049
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Scientific context
AG-1296 is a potent and specific inhibitor of PDGF receptor tyrosine kinase. AG-1296 is cell-permeable.
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Bibliography
1. Strutz F., et al. (2001) Kidney Int. 59(2): 579–592.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of AG1296 (SIH-426), a PDGFR kinase inhibitor. CAS #: 146535-11-7. Molecular Formula: C16H14N2O2. Molecular Weight: 266.3 g/mol. Chemical structure of AG1296, a PDGFR kinase inhibitor (SIH-426). CAS # 146535-11-7. Molecular Formula: C16H14N2O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
