Uteroglobin, human recombinant
-
Catalog number7209-50
-
PricePlease ask
-
Size50 ug
-
-
SynonymsClara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1
-
Alternative_namesClara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1
-
DescriptionExerts anti-inflammatory and anti-tumorigenic effects
-
RecombinantYes
-
SourceE. Coli
-
Purity by SDS PAGE≥98%
-
AssaySDS-PAGE
-
Endotoxin Level< 0.1 ng/ug of protein (
-
Molecular Weight8.0 kDa
-
Storage Temp-20°C
-
ShippingGel Pack
-
Shelf Life12 months
-
AppearanceLyophilized powder
-
Physical form descriptionSterile filtered through a 0.2 micron filter. Lyophilized from 1 X PBS.
-
Reconstitution InstructionsCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
-
Background InformationUteroglobin, a member of the Secretoglobin superfamily, also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. Recombinant Human Uteroglobin is an 8.0 kDa homodimeric protein consisting of 142 amino acid residues.
-
Amino acid sequenceMEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolSCGB3A2, SCGB1A1, SCGB1D1
-
Short nameUteroglobin, recombinant
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHuman, Humans
-
Alternative nameUteroglobin, H. sapiens Rec.
-
Alternative techniquerec
-
Gene info
-
Identity
-
Gene
-
Long gene namesecretoglobin family 3A member 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-03-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Secretoglobins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesecretoglobin family 1A member 1
-
Synonyms gene
-
Synonyms gene name
- uteroglobin
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year1992-11-03
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Secretoglobins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesecretoglobin family 1D member 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2002-03-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Secretoglobins
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data