ASH1, Histone-lysine N-methyltransferase ASH1

• Catalog number
  AS14 2816
• Price
  Please ask
• Size
  50 µg

• Available ordering format
  Lyophilized in PBS pH 7.4
• Immunogen
  N-terminal GST-fusion of the peptide containing amino acids 1756-1855 of the Drosophila melanogaster Ash1protein, UniProt: Q9VW15
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Affinity purified serum
• How to reconstitute
  For reconstitution add 50 µl of sterile water.
• Storage condition
  store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
• Verified applications
  western blot (WB), immunolocalization (IL), chromatin immunoprecipitation (ChIP)
• Connected products
  Secondary antibodies
• Recommended dilutions for use
  1: 1000 (WB), 1:500 (IL), 10ng/ul (ChIP)
• Molecular weight expected аpparent
  236 | 300 kDa
• Verified reactivity
  Drosophila melanogaster
• Possible reactivity
  Drosophila melanogaster
• No reactivity
  no confirmed exceptions from predicted reactivity are currently known
• Supplementary information
  to be added when available
• References
  Kahn et al. (2016). Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements. Nucleic Acids Res. 2016 Aug 23. pii: gkw701. [Epub ahead of print]. Lee et al. (2015). Genome-wide activities of Polycomb complexes control pervasive transcription. Genome Res. 2015 Aug;25(8):1170-81. doi: 10.1101/gr.188920.114. Epub 2015 May 18.
• Scientific context
  Histone-lysine N-methyltransferase ash1 is a Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation.
• Notes
  None
• Protein number
  Q9VW15
• TAIR number
  Refer to NCBI
• Hyperlink

• Gene target
  ASH1   Histone-lysine   N-methyltransferase   ASH1  
• Gene symbol
  ASCL1, ASH1L
• Short name
  ASH1, Histone-lysine N-methyltransferase ASH1
• Alternative name
  ASH1, Histone-lysine N-methyltransferase ASH1

Gene info

• Identity
  HGNC:738
• Gene
  ASCL1
• Long gene name
  achaete-scute family bHLH transcription factor 1
• Synonyms gene name
  • achaete-scute complex (Drosophila) homolog-like 1
  • achaete-scute complex-like 1 (Drosophila)
  • achaete-scute complex homolog 1 (Drosophila)
• Synonyms
  • ASH1
  • HASH1
  • bHLHa46
• GenBank acession
  • L08424
• Locus
  12q23.2
• Discovery year
  1993-12-09
• Entrez gene record
  429
• Pubmed identfication
  • 8390674
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000169967

Gene info

• Identity
  HGNC:19088
• Gene
  ASH1L
• Long gene name
  ASH1 like histone lysine methyltransferase
• Synonyms gene name
  • ash1 (absent, small, or homeotic)-like (Drosophila)
• Synonyms
  • huASH1
  • ASH1
  • ASH1L1
  • KMT2H
• GenBank acession
  • AB037841
• Locus
  1q22
• Discovery year
  2003-08-06
• Entrez gene record
  55870
• Pubmed identfication
  • 10860993
  • 16545939
• RefSeq identity
  • NM_018489
• Classification
  • MicroRNA protein coding host genes
  • Bromodomain containing
  • PHD finger proteins
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000014011

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