UNC5B/UNC5H2 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-11492R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-UNC5B/UNC5H2 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  UNC5B/UNC5H2
• Specificity
  This is a highly specific antibody against UNC5B/UNC5H2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5B
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  Netrin receptor UNC5B; Netrin receptor UNC5B Precursor; p53 regulated receptor for death and le; p53 regulated receptor for death and le protein 1; p53-regulated receptor for death and le protein 1; p53RDL1; Protein unc-5 homolog 2; Protein unc-5 homolog B; Protein XUNC 5; Transmembrane receptor Unc5H2; Unc 5 homolog 2; Unc 5 homolog B; UNC 5B; Unc5 C.elegans homolog b; Unc5b; UNC5B_HUMAN; UNC5H2.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-UNC5B/UNC5H2 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  UNC5B/UNC5H2  
• Gene symbol
  UNC5B, UNC5B-AS1
• Short name
  Anti-UNC5B/UNC5H2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  UNC5B/UNC5H2 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies
• Alternative to gene target
  unc-5 homolog B (C. elegans), UNC5B and IDBG-77562 and ENSG00000107731 and 219699, protein binding, Plasma membranes, Unc5b and IDBG-154989 and ENSMUSG00000020099 and 107449, UNC5B and IDBG-629823 and ENSBTAG00000014270 and 100851524,524942

Gene info

• Identity
  HGNC:12568
• Gene
  UNC5B
• Long gene name
  unc-5 netrin receptor B
• Synonyms gene name
  • unc5 (C.elegans homolog) b
  • unc-5 homolog B (C. elegans)
• Synonyms
  • UNC5H2
  • p53RDL1
• GenBank acession
  • AB096256
• Locus
  10q22.1
• Discovery year
  1998-12-09
• Entrez gene record
  219699
• Pubmed identfication
  • 12655055
  • 20693423
• RefSeq identity
  • NM_170744
• Classification
  • Ig-like cell adhesion molecule family
  • I-set domain containing
• VEGA ID
  OTTHUMG00000018422

Gene info

• Identity
  HGNC:45096
• Gene
  UNC5B-AS1
• Long gene name
  UNC5B antisense RNA 1
• Synonyms
  • UASR1
• Locus
  10q22.1
• Discovery year
  2013-02-14
• Entrez gene record
  728978
• Pubmed identfication
  • 30805847
  • 31205563
• RefSeq identity
  • NR_038453
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000018423

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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