BAY 43-9006, Free base

Alternative_name

Sorafenib
Description

A free base form of BAY 43-9006 (Sorafenib) (Cat. No. 1594-25,100). Acts as an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).
CAS Number

284461-73-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₁₆ClF₃N₄O₃
Molecular Weight

464.82
Cell Permeable

Yes
Purity

≥99% by HPLC
Solubilities

DMSO (200 mg/ml)
Handling

Protect from air and light
Tag Line

A Raf kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
MDL Number

MFCD06411450
PubChem CID

216239
PubChem CID Link
SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChi Key

MLDQJTXFUGDVEO-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

BAY 43-9006 Free base
Gene symbol

IGLV7-43, IGHVII-43-1, SNORD115-43, IGHV3-43, IGKV1D-43, RNU6-43P, SNORD17, TARDBP, CCZ1, RLIM
Short name

BAY 43-9006, Free base
Alternative name

BAY 43-9006, Free base

Identity

HGNC:5680
Gene

IGHVII-43-1
Long gene name

immunoglobulin heavy variable (II)-43-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-43-1
- immunoglobulin heavy variable (II)-43-1 pseudogene
Synonyms
- IGHV(II)-43-1
GenBank acession
- AB019438
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28367
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000191837

Identity

HGNC:11571
Gene

TARDBP
Long gene name

TAR DNA binding protein
Synonyms
- TDP-43
- ALS10
GenBank acession
- U23731
Locus

1p36.22
Discovery year

2000-01-28
Entrez gene record

23435
Pubmed identfication
- 7745706
- 31039256
RefSeq identity
- NM_007375
Classification
- RNA binding motif containing
VEGA ID

OTTHUMG00000002120
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
- LRG_659

Identity

HGNC:21691
Gene

CCZ1
Long gene name

CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Synonyms gene
- C7orf28A
Synonyms gene name
- chromosome 7 open reading frame 28A
- CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
Synonyms
- CGI-43
- CCZ1A
GenBank acession
- AF151801
Locus

7p22.1
Discovery year

2003-07-14
Entrez gene record

51622
Pubmed identfication
- 10810093
- 20305638
RefSeq identity
- NM_015622
VEGA ID

OTTHUMG00000155502