PJ-34, PARP inhibitor

• Catalog number
  SIH-366-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  344458-15-7
• Description
  PARP inhibitor
• Molecular weight
  331,8 g/mol
• Primary research fields
  Cancer, Apoptosis, Cancer Growth Inhibitors, PARP Inhibitors
• Other name
  N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,Ndimethylacetamide . HCl
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C17H17N3O2•HCL•H2O
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (HPLC); NMR (Conforms)
• Soluble in
  May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
• Physical appearance
  White to yellow solid.
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  4858
• Scientific context
  PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).
• Bibliography
  1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.
• Release date
  4-Apr-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of PJ-34 (SIH-366), a PARP inhibitor. CAS #: 344458-15-7. Molecular Formula: C17H17N3O2 *HCL * H2O. Molecular Weight: 331.8 g/mol. Chemical structure of PJ-34, a PARP inhibitor (SIH-366). CAS # 344458-15-7. Molecular Formula: C17H17N3O2 *HCL * H2O.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PJ-34   PARP   inhibitor  
• Gene symbol
  SNORD115-34, IGKV3D-34, IGKV3-34, IGHV4-34, IGLV2-34, IGHV7-34-1, TNKS2, TIPARP, PARP1, RNU6-34P
• Short name
  PJ-34, PARP inhibitor
• Alternative name
  PJ-34, PARP suppressor

Gene info

• Identity
  HGNC:33053
• Gene
  SNORD115-34
• Long gene name
  small nucleolar RNA, C/D box 115-34
• Synonyms
  • HBII-52-34
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033808
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003349.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5828
• Gene
  IGKV3D-34
• Long gene name
  immunoglobulin kappa variable 3D-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3D-34
  • immunoglobulin kappa variable 3D-34 pseudogene
• GenBank acession
  • X71895
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28871
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151601

Gene info

• Identity
  HGNC:5820
• Gene
  IGKV3-34
• Long gene name
  immunoglobulin kappa variable 3-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3-34
  • immunoglobulin kappa variable 3-34 pseudogene
• GenBank acession
  • X71891
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28909
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151693

Gene info

• Identity
  HGNC:5650
• Gene
  IGHV4-34
• Long gene name
  immunoglobulin heavy variable 4-34
• GenBank acession
  • X92278
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28395
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152074

Gene info

• Identity
  HGNC:5893
• Gene
  IGLV2-34
• Long gene name
  immunoglobulin lambda variable 2-34 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 2-34
  • immunoglobulin lambda variable 2-34 pseudogene
• GenBank acession
  • D87013
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28810
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151174

Gene info

• Identity
  HGNC:5664
• Gene
  IGHV7-34-1
• Long gene name
  immunoglobulin heavy variable 7-34-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 7-34-1
  • immunoglobulin heavy variable 7-34-1 pseudogene
• GenBank acession
  • AB019439
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28382
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152085

Gene info

• Identity
  HGNC:15677
• Gene
  TNKS2
• Long gene name
  tankyrase 2
• Synonyms gene name
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
• Synonyms
  • TNKL
  • TANK2
  • PARP-5b
  • PARP-5c
  • PARP5B
  • PARP5C
  • pART6
  • ARTD6
• Synonyms name
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2
• GenBank acession
  • AF342982
• Locus
  10q23.32
• Discovery year
  2001-05-10
• Entrez gene record
  80351
• RefSeq identity
  • NM_025235
• Classification
  • Poly(ADP-ribose) polymerases
  • Sterile alpha motif domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000018747

Gene info

• Identity
  HGNC:23696
• Gene
  TIPARP
• Long gene name
  TCDD inducible poly(ADP-ribose) polymerase
• Synonyms gene name
  • TCDD-inducible poly(ADP-ribose) polymerase
• Synonyms
  • DKFZP434J214
  • DKFZp686N0351
  • DDF1
  • PARP7
  • PARP-7
  • PARP-1
  • pART14
  • RM1
  • ARTD14
• GenBank acession
  • BX537965
• Locus
  3q25.31
• Discovery year
  2003-12-02
• Entrez gene record
  25976
• Pubmed identfication
  • 12851707
• RefSeq identity
  • NM_015508
• Classification
  • Poly(ADP-ribose) polymerases
• VEGA ID
  OTTHUMG00000158646

Gene info

• Identity
  HGNC:270
• Gene
  PARP1
• Long gene name
  poly(ADP-ribose) polymerase 1
• Synonyms gene
  • PPOL
  • ADPRT
• Synonyms gene name
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • poly (ADP-ribose) polymerase family, member 1
• Synonyms
  • PARP
  • ARTD1
• GenBank acession
  • BC037545
• Locus
  1q42.12
• Discovery year
  1986-01-01
• Entrez gene record
  142
• Pubmed identfication
  • 10964595
• RefSeq identity
  • NM_001618
• Classification
  • Zinc fingers PARP-type
  • Zinc fingers
  • Poly(ADP-ribose) polymerases
• VEGA ID
  OTTHUMG00000037556

Gene info

• Identity
  HGNC:34278
• Gene
  RNU6-34P
• Long gene name
  RNA, U6 small nuclear 34, pseudogene
• Synonyms gene
  • RNU6-34
• Synonyms gene name
  • RNA, U6 small nuclear 34
• Locus
  4q22.3
• Discovery year
  2008-06-10
• Entrez gene record
  100873749
• RefSeq identity
  • NR_046492

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