anti-MACC1 Antibody

  • Catalog number
    5197
  • Price
    Please ask
  • Size
    0.02 mg, 0.1 mg
  • Gene info
    MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
  • Gene names
    MACC1 Antibody: 7A5, SH3BP4L, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5
  • Antibodie s label
    unlabelled serum
  • Purity
    MACC1 Antibody is affinity chromatography purified via peptide column.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Immunoglobulin
    IgG
  • Spicific to
    At least two isoforms of MACC1 are known to exist.
  • Antigen
    MACC1 antibody was made against a 17 amino acid synthetic peptide near the center of human MACC1.
  • Immuno application
    ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
  • Antibody advice
    MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.
  • Suspention pH azide
    MACC1 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Keep at
    MACC1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Works with
    Human, Mouse, Rat
  • Omim nr
    157502191
  • Ncbi nr
    NP_877439
  • KDa
    Predicted: 94 kDa Observed: 90 kDa
  • Vial with antibody
    in solution
  • Quantity per ml
    1 mg/mL
  • NCBI GENE nr
    346389
  • GENE symbol
    MACC1
  • Antigene name
    metastasis associated in colon cancer 1
  • Source
    Homo sapiens
  • Protein nr
    Q6ZN28
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    MACC1  
  • Gene symbol
    MACC1-AS1, MACC1-DT, MACC1
  • Short name
    anti-MACC1 Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toMACC1 (antibody to-)
  • Alternative technique
    antibodies
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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