anti-MACC1 Antibody
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Catalog number5197
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoMACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
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Gene namesMACC1 Antibody: 7A5, SH3BP4L, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5
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Antibodie s labelunlabelled serum
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PurityMACC1 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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Spicific toAt least two isoforms of MACC1 are known to exist.
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AntigenMACC1 antibody was made against a 17 amino acid synthetic peptide near the center of human MACC1.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody adviceMACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azideMACC1 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atMACC1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr157502191
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Ncbi nrNP_877439
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KDaPredicted: 94 kDa Observed: 90 kDa
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr346389
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GENE symbolMACC1
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Antigene namemetastasis associated in colon cancer 1
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SourceHomo sapiens
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Protein nrQ6ZN28
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMACC1-AS1, MACC1-DT, MACC1
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Short nameanti-MACC1 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toMACC1 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameMACC1 antisense RNA 1
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Synonyms gene name
- MACC1 antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year2012-02-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMACC1 divergent transcript
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Locus
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Discovery year2021-07-05
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Entrez gene record
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RefSeq identity
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene nameMET transcriptional regulator MACC1
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Synonyms gene name
- metastasis associated in colon cancer 1
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Synonyms
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Locus
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Discovery year2008-10-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data