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15-PGDH Inhibitor Screening Kit (Fluorometric)

15-PGDH Inhibitor Screening Kit (Fluorometric) is available 1 time from Biovision labs

K503-100 | 15-PGDH Inhibitor Screening Kit (Fluorometric) size: 100 assays | 985.70 USD

Catalog number K503-100
Supplier Biovision
Price 985.70 USD
Size 100 assays
1. Gene info
Identity 8923
Gene PHGDH
Long gene name phosphoglycerate dehydrogenase
Synonyms
  • SERA
  • PGDH
  • PDG
Synonyms name
  • D-3-phosphoglycerate dehydrogenase
GenBank acession
  • BC011262
Locus 1p12
Discovery year 1999-11-22
Entrez gene record 26227
RefSeq identity
  • NM_006623
Havana BLAST/BLAT OTTHUMG00000012100
Product images
    #0#.jpeg15-PGDH Inhibitor Screening Kit (Fluorometric)
Kit's description 15-hydroxyprostaglandin dehydrogenase (15-PGDH, EC: 1.1.1.141) catalyzes the oxidation of Prostaglandins (PG) to 15-keto metabolites which show greatly reduced biological activity when compared to Prostaglandins. 15-PGDH catalyzes the rate-limiting step of PG catabolism. More recently, the inhibition of 15-PGDH has been reported as a negative regulator of tissue repair and inhibition of this enzyme can potentiate tissue regeneration in mouse models. Thus, pharmacological inhibition of 15-PGDH could have clinical implications by accelerating potential tissue regeneration after damage. In this assay, 15-PG is oxidized by 15-PDGH generating 15-Keto metabolites and oxidizing NAD. NADH reduces a Fluorometric probe thus, generating an enhanced and stable fluorescence signal (Ex/Em=535/587 nm). In the presence of an inhibitor, the enzymatic activity is inhibited resulting No/Low fluorescence. BioVision’s 15-PGDH Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of 15-PGDH inhibitors.
Highlights • Detection method: Fluorescence (Ex/Em = 535/587 nm) • Applications: Screening/studying/characterizing 15:PGDH inhibitors.
Kit's benefits • Simple method to screen 15-PGDH inhibitors • High-throughput Compatible • Includes 15-PGDH Inhibitor Control,
Category Signal Transduction, 15-PGDH
Kit's other name Prostaglandin-Endoperoxide Synthase 2 Inhibitor Screening Kit (Fluorometric), PTGS2 Inhibitor Screening Kit (Fluorometric)
Contents • 15-PGDH Assay Buffer • PicoProbeTM Probe (in DMSO) • 15-PGDH Developer • 15-PGDH Substrate (in DMSO) • 15-PGDH Enzyme • 15-PGDH Inhibitor Control (in DMSO)
Storage condition -20°C
Shipping condition gel pack
Maximum time can be stored 12 months
Species reactivity see datasheet
Applications Screening/studying/characterizing 15-PGDH inhibitors.
Description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene target15-PGDH Inhibitor Screening Kit Fluorometric
Short name 15-PGDH Inhibitor Screening Kit (Fluorometric)
Alternative name 15-PGDH suppressor quantification reagent (fluorescence)
Alternative technique kits
Alternative to gene target v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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15-PGDH Inhibitor Screening Kit (Fluorometric) | Technique a
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  • 15-PGDH
  • Inhibitor
  • Screening
  • Kit
  • Fluorometric
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