Astemizole, Herg channel blocker

  • Catalog number
    SIH-302-50MG
  • Price
    Please ask
  • Size
    50 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    68844-77-9
  • Description
    Herg channel blocker
  • Molecular weight
    458,57 g/mol
  • Primary research fields
    Neuroscience, Ion Channels
  • Other name
    1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C28H31FN4O
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Physical appearance
    White solid
  • Storage recommendations
    -20ÂșC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62 - Possible risk of impaired fertility Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
  • PubChem number
    2247
  • Scientific context
    Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
  • Bibliography
    1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300. 2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.
  • Release date
    8-Apr-2011
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol. Chemical structure of Astemizole, a Herg channel blocker (SIH-302). CAS # 68844-77-9. Molecular Formula: C28H31FN4O.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.05
  • Gene target
  • Short name
    Astemizole, Herg channel blocker
  • Alternative name
    Astemizole, Herg channel blocker
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