Astemizole, Herg channel blocker
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Catalog number
SIH-302-50MG
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Price
Please ask
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Size
50 mg
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Stock availabilitIn Stock
In Stock
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CAS number
68844-77-9
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Description
Herg channel blocker
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Molecular weight
458,57 g/mol
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Primary research fields
Neuroscience, Ion Channels
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Other name
1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C28H31FN4O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 100 mM in DMSO and to 25 mM in ethanol
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Physical appearance
White solid
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Storage recommendations
-20ÂșC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62 - Possible risk of impaired fertility Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
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PubChem number
2247
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Scientific context
Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
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Bibliography
1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300. 2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Astemizole (SIH-302), a Herg channel blocker. CAS #: 68844-77-9. Molecular Formula: C28H31FN4O. Molecular Weight: 458.57 g/mol. Chemical structure of Astemizole, a Herg channel blocker (SIH-302). CAS # 68844-77-9. Molecular Formula: C28H31FN4O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Gene target
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Short name
Astemizole, Herg channel blocker
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Alternative name
Astemizole, Herg channel blocker
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