Recombinant Human IL-1 Receptor Accessory Protein/IL-1RAcP/IL-1R3 Protein(C-Fc-6His)

  • Catalog number
    PKSH032559-10µg
  • Price
    Please ask
  • Size
    10µg
  • Synonym
    Interleukin-1 Receptor Accessory Protein; IL-1 Receptor Accessory Protein; IL-1RAcP; Interleukin-1 Receptor 3; IL-1R-3; IL-1R3; IL1RAP; C3orf13; IL1R3
  • Activity
    NA
  • Sequence
    Ser21-Gln356
  • Fusion tag
    C-Fc-6His
  • Accession
    Q9NPH3
  • Expressed Host
    Human cells
  • Shipping
    The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
  • Purity
    >95% as determined by reducing SDS-PAGE.
  • Endotoxin
    <1.0 EU per µg as determined by LAL test.
  • Stability and Storage
    Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
  • Mol Mass
    39.7 kDa
  • AP Mol Mass
    82 kDa
  • Formulation
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
  • Background
    Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α, IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene
    The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.
  • Description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    IL1F10, IL1RAP, IL36G, IL25, IL22, IL18, IL37, IL1B, IL1A, IL19
  • Short name
    Recombinant IL-1 Receptor Accessory Protein/IL-1RAcP/IL-1R3 Protein(C-Fc-6His)
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    Rec. H. sapiens Interleukin-1 Receptor Accessory Protein/Interleukin-1RAcP/Interleukin-1R3 Protein(C-fragment c-6His)
  • Alternative technique
    rec
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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