Recombinant Human IL-1 Receptor Type 2/IL-1R-2 Protein(C-Fc) 50µg

• Catalog number
  PKSH032561-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD121b
• Activity
  NA
• Sequence
  Phe14-Glu343
• Fusion tag
  C-Fc
• Accession
  P27930
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  64.5 kDa
• AP Mol Mass
  80-95 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Reconstitution
  Please refer to it for detailed information.
• Background
  Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Gene
  The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL-1   Receptor   2/IL-1R-2   Protein   C-Fc   50µg  
• Gene symbol
  IL1A, IL1B, IL1F10, IL2, IL19, IL36B, IL36G, IL25, IL22, IL18
• Short name
  Recombinant IL-1 Receptor 2/IL-1R-2 Protein(C-Fc) 50µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Interleukin-1 Receptor classification 2/Interleukin-1R-2 Protein(C-fragment c) 50µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:5991
• Gene
  IL1A
• Long gene name
  interleukin 1 alpha
• Synonyms gene
  • IL1
• Synonyms
  • IL1F1
  • IL-1A
  • IL1-ALPHA
• Synonyms name
  • preinterleukin 1 alpha
  • hematopoietin-1
  • pro-interleukin-1-alpha
• GenBank acession
  • M28983
• Locus
  2q14.1
• Discovery year
  2001-06-22
• Entrez gene record
  3552
• Pubmed identfication
  • 8188271
  • 2989698
• RefSeq identity
  • NM_000575
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131315

Gene info

• Identity
  HGNC:5992
• Gene
  IL1B
• Long gene name
  interleukin 1 beta
• Synonyms
  • IL1F2
  • IL-1B
  • IL1-BETA
• GenBank acession
  • M15330
• Locus
  2q14.1
• Discovery year
  1989-03-31
• Entrez gene record
  3553
• Pubmed identfication
  • 2954882
  • 2989698
• RefSeq identity
  • NM_000576
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131344

Gene info

• Identity
  HGNC:15552
• Gene
  IL1F10
• Long gene name
  interleukin 1 family member 10
• Synonyms gene name
  • interleukin 1 family, member 10 (theta)
• Synonyms
  • FKSG75
  • IL-1HY2
  • IL-1F10
  • IL1-theta
  • MGC11983
  • MGC119832
  • MGC119833
• Synonyms name
  • FIL1- theta
  • interleukin-1 receptor antagonist FKSG75
• GenBank acession
  • AY026753
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  84639
• Pubmed identfication
  • 11747621
  • 11991723
  • 11991722
• RefSeq identity
  • NM_173161
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131339

Gene info

• Identity
  HGNC:6001
• Gene
  IL2
• Long gene name
  interleukin 2
• Synonyms
  • IL-2
  • TCGF
• Synonyms name
  • T cell growth factor
• GenBank acession
  • U25676
• Locus
  4q27
• Discovery year
  1986-01-01
• Entrez gene record
  3558
• Pubmed identfication
  • 3260003
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000133075

Gene info

• Identity
  HGNC:5990
• Gene
  IL19
• Long gene name
  interleukin 19
• Synonyms
  • IL-19
  • MDA1
  • ZMDA1
  • IL-10C
  • NG.1
• Synonyms name
  • melanoma differentiation associated protein-like protein
• GenBank acession
  • AF192498
• Locus
  1q32.1
• Discovery year
  2000-03-29
• Entrez gene record
  29949
• Pubmed identfication
  • 11196675
• RefSeq identity
  • NM_153758
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000036387

Gene info

• Identity
  HGNC:15564
• Gene
  IL36B
• Long gene name
  interleukin 36 beta
• Synonyms gene
  • IL1F8
• Synonyms gene name
  • interleukin 1 family, member 8 (eta)
• Synonyms
  • FIL1
  • IL-1H2
  • IL-1F8
  • FILI-(ETA)
  • IL1-ETA
  • IL1H2
  • MGC126880
  • MGC126882
• GenBank acession
  • AF201833
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  27177
• Pubmed identfication
  • 10625660
  • 10512743
  • 16646978
• RefSeq identity
  • NM_014438
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131338

Gene info

• Identity
  HGNC:15741
• Gene
  IL36G
• Long gene name
  interleukin 36 gamma
• Synonyms gene
  • IL1F9
• Synonyms gene name
  • interleukin 1 family, member 9
• Synonyms
  • IL-1H1
  • IL-1RP2
  • IL-1F9
  • IL1H1
  • IL1E
• Synonyms name
  • interleukin-1 homolog 1
  • interleukin 1-related protein 2
  • interleukin-1 epsilon
• GenBank acession
  • AF200492
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  56300
• Pubmed identfication
  • 10860666
  • 10744718
  • 11991722
  • 11991723
• RefSeq identity
  • NM_019618
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131336

Gene info

• Identity
  HGNC:13765
• Gene
  IL25
• Long gene name
  interleukin 25
• Synonyms gene
  • IL17E
• Synonyms gene name
  • interleukin 17E
• Synonyms
  • IL-25
  • IL-17E
• GenBank acession
  • AF305200
• Locus
  14q11.2
• Discovery year
  2001-01-26
• Pubmed identfication
  • 11058597
  • 11754819
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000028749

Gene info

• Identity
  HGNC:14900
• Gene
  IL22
• Long gene name
  interleukin 22
• Synonyms
  • ILTIF
  • IL-21
  • zcyto18
  • IL-TIF
  • IL-D110
  • TIFa
  • TIFIL-23
  • IL-22
  • MGC79382
  • MGC79384
• Synonyms name
  • IL-10-related T-cell-derived inducible factor
• GenBank acession
  • AF279437
• Locus
  12q15
• Discovery year
  2001-03-12
• Entrez gene record
  50616
• Pubmed identfication
  • 10954742
  • 10875937
• RefSeq identity
  • NM_020525
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000169119
• Locus Specific Databases
  • LRG_1248

Gene info

• Identity
  HGNC:5986
• Gene
  IL18
• Long gene name
  interleukin 18
• Synonyms gene name
  • interleukin 18 (interferon-gamma-inducing factor)
• Synonyms
  • IGIF
  • IL1F4
  • IL-1g
  • IL-18
• Synonyms name
  • interferon-gamma-inducing factor
• GenBank acession
  • U90434
• Locus
  11q23.1
• Discovery year
  1997-07-25
• Entrez gene record
  3606
• Pubmed identfication
  • 7477296
  • 9693051
• RefSeq identity
  • NM_001562
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000167006

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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