AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.
Is it cell-permeable?
≥98% by TLC
Is this a salt?
Protect from light and air
Maximum time for storage
Light brown solid
DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
For cells, cell lines and tissues in culture till half confluency.