TREM2, human recombinant

• Catalog number
  7357-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
• Alternative_names
  Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
• Description
  Involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF.
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Concentration
  0.25 mg/ml
• Appearance
  Liquid
• Physical form description
  0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
• Background Information
  TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Amino acid sequence
  MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  TREM2  
• Gene symbol
  TREM2
• Short name
  TREM2, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  triggering receptor expressed on myeloid cells 2, H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  triggering receptor expressed on myeloid cells 2, TREM2 and IDBG-86566 and ENSG00000095970 and 54209, scaffold protein binding, Extracellular, Trem2 and IDBG-189871 and ENSMUSG00000023992 and 83433, TREM2 and IDBG-630863 and ENSBTAG00000007275 and 506467

Gene info

• Identity
  HGNC:17761
• Gene
  TREM2
• Long gene name
  triggering receptor expressed on myeloid cells 2
• Synonyms gene name
  • triggering receptor expressed on myeloid cells 2a
• Synonyms
  • TREM-2
  • Trem2a
  • Trem2b
  • Trem2c
• GenBank acession
  • AF213457
• Locus
  6p21.1
• Discovery year
  2002-08-09
• Entrez gene record
  54209
• Pubmed identfication
  • 10799849
  • 12080485
• RefSeq identity
  • NM_018965
• Classification
  • V-set domain containing
• VEGA ID
  OTTHUMG00000014671
• Locus Specific Databases
  • LRG_631

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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