Caspase-6 Substrate VEID-AFC

• Catalog number
  1069-200
• Price
  Please ask
• Size
  200 assays

• Alternative_name
  Ac-VEID-AFC, Caspase-6 Substrate, Fluorogenic, VEID-AFC
• Description
  Ready-to-use fluorometric substrate for caspase-6 and related caspases that recognize the amino acid sequence VEID. Caspase-6 and related caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the peptide substrate VEID-AFC at Ex/Em = 400/505, using a fluorometer or multi-well fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized, using a hand-held long-UV lamp. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase-6 assays. Cell Lysis Buffer (Cat. #1067-100, -400) and 2X Reaction Buffer (Cat. #1068-20, -80) for caspase assays are also available separately.
• Structure Available
  No
• Peptide sequence
  Ac-Val-Glu-Ile-Asp-AFC
• Salt Form
  No
• Molecular Formula
  C₃₂H₄₀F₃N₅O₁₁
• Molecular Weight
  727.7
• Cell Permeable
  No
• Purity
  >95% by HPLC
• Handling
  Protect from light and moisture
• Tag Line
  A caspase-6 substrate
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• MDL Number
  MFCD01318833
• PubChem CID
  44135099
• PubChem CID Link
• SMILES
  CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C
• InChi
  InChI=1S/C32H40F3N5O11/c1-6-15(4)27(40-28(47)20(9-10-23(42)43)38-30(49)26(14(2)3)36-16(5)41)31(50)39-21(13-24(44)45)29(48)37-17-7-8-18-19(32(33,34)35)12-25(46)51-22(18)11-17/h7-8,11-12,14-15,20-21,26-27H,6,9-10,13H2,1-5H3,(H,36,41)(H,37,48)(H,38,49)(H,39,50)(H,40,47)(H,42,43)(H,44,45)
• InChi Key
  RPBOFHGWCDGAEG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

• Gene target
  Caspase-6   Substrate   VEID-AFC  
• Short name
  Caspase-6 Substrate VEID-AFC
• Alternative name
  caspase-6 Substrate VEID-AFC

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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