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EZH2 Inhibitor EPZ005687

EZH2 Inhibitor EPZ005687 is available 3 times from Biovision labs

2364-2 | EZH2 Inhibitor, EPZ005687 size: 2 mg | 304.59 USD

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2364-10 | EZH2 Inhibitor, EPZ005687 size: 10 mg | 626.42 USD

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2364-2 | EZH2 Inhibitor, EPZ005687 for cell activation size: 2 mg | 201.15 USD

Additional description For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Short name EZH2 Inhibitor, EPZ005687 for activation
Technique activation
Alternative name EZH2 suppressor, EPZ005687 to measure cellular activation
Tissue cell
1. Gene info
Identity3527
GeneEZH2
Long gene name enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms gene name
  • enhancer of zeste (Drosophila) homolog 2
  • enhancer of zeste homolog 2 (Drosophila)
Locus7q36.1
Discovery year 1995-12-21
Entrez gene record2146
Pubmed identfication
RefSeq identity
Classification
  • SET domain containing
  • Polycomb repressive complex 2
  • Lysine methyltransferases
  • Myb/SANT domain containing
Havana BLAST/BLATOTTHUMG00000158973
Locus Specific Databases
Additional information
Product images
    EZH2 Inhibitor, EPZ005687
Product files
Description A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.
Peptide sequence N/A
CAS number 1396772-26-1
Molecular weight 539.67
Category Biochemicals
Other name 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Molecular formula C₃₂H₃₇N₅O₃
Physical appearance White solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? No
Purification ≥99%HPLC
Reconstitute instructions DMSO
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and light
Alternate Name/Synonyms 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Appearance White solid
Formulation N/A
CAS Number 1396772-26-1
Molecular Formula C₃₂H₃₇N₅O₃
Molecular Weight 539.67
Purity ≥99%HPLC
Solubility/Reconstitution Instructions DMSO
Handling Protect from air and light
Tagline A potent EZH2 inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 36 months
MDL Number N/A
PubChem CID 60160561
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