EZH2 Inhibitor, EPZ005687
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Catalog number
2364-10
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Price
Please ask
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Size
10 mg
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Alternative_name
1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
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Description
A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.
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CAS Number
1396772-26-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₃₂H₃₇N₅O₃
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Molecular Weight
539.67
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Cell Permeable
No
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Purity
≥99%HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
A potent EZH2 inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
60160561
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SMILES
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
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InChi
InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
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InChi Key
ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
EZH2
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Short name
EZH2 Inhibitor, EPZ005687
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Alternative name
EZH2 suppressor, EPZ005687
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Gene info
Product images
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