EZH2 Inhibitor, EPZ005687

  • Catalog number
    2364-10
  • Price
    Please ask
  • Size
    10 mg
  • Alternative_name
    1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
  • Description
    A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.
  • CAS Number
    1396772-26-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₃₂H₃₇N₅O₃
  • Molecular Weight
    539.67
  • Cell Permeable
    No
  • Purity
    ≥99%HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent EZH2 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    60160561
  • SMILES
    CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
  • InChi
    InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
  • InChi Key
    ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    EZH2
  • Short name
    EZH2 Inhibitor, EPZ005687
  • Alternative name
    EZH2 suppressor, EPZ005687
Gene info
  • Identity
  • Gene
  • Long gene name
    enhancer of zeste 2 polycomb repressive complex 2 subunit
  • Synonyms gene name
    • enhancer of zeste (Drosophila) homolog 2
    • enhancer of zeste homolog 2 (Drosophila)
  • Synonyms
  • Locus
  • Discovery year
    1995-12-21
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • SET domain containing
    • Polycomb repressive complex 2
    • Lysine methyltransferases
    • Myb/SANT domain containing
  • VEGA ID
  • Locus Specific Databases
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