BAY 11-7082

  • Catalog number
    1867-10
  • Price
    Please ask
  • Size
    10 mg
  • Alternative_name
    (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
  • Description
    Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC₅₀ values of 5-10 µM.
  • CAS Number
    19542-67-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₀H₉NO₂S
  • Molecular Weight
    207.25
  • Cell Permeable
    Yes
  • Purity
    ≥98%
  • Solubilities
    DMSO or EtOH
  • Handling
    Protect from air and light
  • Tag Line
    A NF-κB activation inhibitor
  • Storage Condition
    +4°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD00712162
  • PubChem CID
    5353431
  • SMILES
    CC1=CC=C(C=C1)S(=O)(=O)C=CC#N
  • InChi
    InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
  • InChi Key
    DOEWDSDBFRHVAP-KRXBUXKQSA-N
  • MSDS Available
    Yes
  • Gene target
    BAY   11-7082  
  • Gene symbol
    PIRC52, IGKV1OR2-11, PIRC51, PIRC50, SNORD114-11, SNORD116-11, SNORD115-11, IGHV3OR16-11
  • Short name
    BAY 11-7082
  • Alternative name
    BAY 11-7082
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 52
  • Locus
    11
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin kappa variable 1/OR2-11 (pseudogene)
  • Synonyms gene name
    • immunoglobulin kappa variable 1/OR2-11
    • immunoglobulin kappa variable 1/OR2-11 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-18
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Immunoglobulin kappa (IGK) orphons
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 51
  • Locus
    11
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 50
  • Locus
    11
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 3/OR16-11 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable 3/OR16-11
    • immunoglobulin heavy variable 3/OR16-11 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • Classification
    • Immunoglobulin heavy (IGH) orphons
  • VEGA ID
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