BAY 11-7082
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Catalog number1867-10
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PricePlease ask
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Size10 mg
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Alternative_name(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
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DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC₅₀ values of 5-10 µM.
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CAS Number19542-67-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₀H₉NO₂S
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Molecular Weight207.25
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Cell PermeableYes
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Purity≥98%
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SolubilitiesDMSO or EtOH
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HandlingProtect from air and light
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Tag LineA NF-κB activation inhibitor
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Storage Condition+4°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD00712162
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PubChem CID5353431
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SMILESCC1=CC=C(C=C1)S(=O)(=O)C=CC#N
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InChiInChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
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InChi KeyDOEWDSDBFRHVAP-KRXBUXKQSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolPIRC52, IGKV1OR2-11, PIRC51, PIRC50, SNORD114-11, SNORD116-11, SNORD115-11, IGHV3OR16-11
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Short nameBAY 11-7082
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Alternative nameBAY 11-7082
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Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 52
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 1/OR2-11 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 1/OR2-11
- immunoglobulin kappa variable 1/OR2-11 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin kappa (IGK) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 51
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 50
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-11
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-11
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-11
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3/OR16-11 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable 3/OR16-11
- immunoglobulin heavy variable 3/OR16-11 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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Classification
- Immunoglobulin heavy (IGH) orphons
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VEGA ID