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Alternative_name
2-(Phosphonomethyl)pentane-1,5-dioic acid; PMPA
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Description
PMPA is a highly potent and selective inhibitor of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase or glutamate carboxypeptidase II or GCPII) with a Ki value of 275 pM. Displays robust neuroprotective activity in both in vitro and in vivo models of ischemia.
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CAS Number
173039-10-6
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Structure Available
Yes
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Molecular Formula
C₆H₁₁O₇P
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Molecular Weight
226.12
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Cell Permeable
Yes
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Purity
≥95% by NMR
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Solubilities
H₂O (>20 mg/ml)
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Handling
Protect from moisture
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Tag Line
A potent NAALADase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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PubChem CID
10130754
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SMILES
C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
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InChi
InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
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InChi Key
ISEYJGQFXSTPMQ-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
