IL-17A Recombinant Protein

  • Catalog number
    40-423
  • Price
    Please ask
  • Size
    0.005 mg, 0.025 mg
  • About recombinant protein
    The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.
  • Other name of the recombinant
    Il17, Ctla8, IL-17, Ctla-8, IL-17A, Il17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8
  • Recombinant in
    E. coli
  • SEQUENCE
    MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
  • Activity
    Biological activity was measured by its ability to induce IL - 6 production by NIH 3T3 cells.
  • Keep at
    The lyophilized IL-17A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IL-17A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IL-17A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec PROTEIN GI
    6754324
  • Accession nr
    NP_034682.1
  • Pureity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin level is less than 0.1 ng per μg (1EU/μg).
  • About
    This product is for research use only.
  • Protein s origin
    Murine
  • Vial
    Lyophilized
  • NCBI ID
    16171
  • Gene name
    interleukin 17A
  • Source
    Mus musculus
  • Uniprot
    Q62386
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    IL-17A   Protein  
  • Gene symbol
    Il17a
  • Short name
    IL-17A Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    Interleukin-17A Rec. Protein
  • Alternative technique
    rec
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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