MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme

• Catalog number
  X1661E
• Price
  Please ask
• Size
  20 μg

• Category
  Proteins & Peptides
• Long description
  MEG-1, also know as Serine/threonine phosphatase 4 regulatory subunit 1, PPP4R1 or PP4R1 is crucial to cellular function. The catalytic subunit of MEG-1 or protein phosphatase 4 (PP4C) is 65% identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. MEG-1 has been highly conserved between species sharing 91% amino acid identity between human and Drosophila. MEG-1 is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. MEG-1 is an essential enzyme in the development of Drosophila embryos.
• Antibody come from
  Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Ser133 of CREB
• Other description
  Provided in HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg per ml BSA and 50% glycerol .
• Clone
  not specified
• Antigen antibody binding interaction
  MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme
• Antibody is raised in
  E.coli
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
• Antibody s suited for
  Antibody can be used for Western blotting and dot blotting (1:1000 dilution). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Abel, T. and Kandel, E. 'Positive and negative regulatory mechanisms that mediate long-term memory storage,' Brain Res. Rev. 26, 360-378 (1998)._x000B__x000B_2. Hunter, T. and Karin, 'The regulation of transcription by phosphorylation,' Cell 70, 375-387 (1992)._x000B__x000B_3, Johannessen, M, Delghandi, M.P. and Moens, U. 'What turns CREB on?' Cellular Signaling 16, 1211-1227 (2004)._x000B__x000B_4. Montminy, M. 'Transcriptional regulation by cyclic AMP,' Annu. Rev. Biochem. 66, 807-822 (1997)._x000B__x000B_5. Shaywitz, A.J. and Greenberg, M.E. 'CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals,' Annu. Rev. Biochem. 68, 821-861 (1999)._x000B__x000B_6. Silva, A.J., Kogan, J.H., Frankland, P.W. and Kida, S. 'CREB and memory,' Annu. Rev. Neurosci. 21, 127-148 (1998)._x000B__x000B_7. Soderling, T.R. and Derkach, V.A. 'Postsynaptic protein phosphorylation and LTP,' Trends Neurosci. 23, 75-80 (2000)._x000B__x000B_8. Karin M, Hunter T (1995) Transcriptional control by protein phosphorylation: Signal transmission from the cell surface_x000B_to the nucleus. Curr Biol 5:747-757. _x000B__x000B_9. Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia ZG, Greenberg ME_x000B_(2002) CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events._x000B_Neuron 34:221-233.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.

• Gene target
  MEG-1   637-926   PTPN4   GST   Tag   Active  
• Gene symbol
  PTPN4, MGST3, MIR637, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1, MIR101-1
• Short name
  MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme
• Technique
  Enzyme, enzymes, Tags
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  MEG-1 (637-926)/PTPN4 N-Terminal GST detection labelled - functionnal Enzyme
• Alternative technique
  enzymes

Gene info

• Identity
  HGNC:9656
• Gene
  PTPN4
• Long gene name
  protein tyrosine phosphatase non-receptor type 4
• Synonyms gene name
  • protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
• Synonyms
  • PTPMEG
• Locus
  2q14.2
• Discovery year
  1992-02-12
• Entrez gene record
  5775
• Pubmed identfication
  • 1648233
• Classification
  • PDZ domain containing
  • FERM domain containing
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000131436

Gene info

• Identity
  HGNC:7064
• Gene
  MGST3
• Long gene name
  microsomal glutathione S-transferase 3
• Synonyms
  • GST-III
• Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
• GenBank acession
  • AF026977
• Locus
  1q24.1
• Discovery year
  1997-10-16
• Entrez gene record
  4259
• Pubmed identfication
  • 9278457
• RefSeq identity
  • NM_004528
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000034627

Gene info

• Identity
  HGNC:32893
• Gene
  MIR637
• Long gene name
  microRNA 637
• Synonyms gene
  • MIRN637
• Synonyms
  • hsa-mir-637
• Locus
  19p13.3
• Discovery year
  2006-05-17
• Entrez gene record
  693222
• RefSeq identity
  • NR_030367
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

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