BAY 11 7082, IKK kinase inhibitor

  • Catalog number
    SIH-434-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    19542-67-7
  • Description
    IKK kinase inhibitor
  • Molecular weight
    207,3 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C10H9NO2S
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble to 25 mM in ethanol and to 100 mM in DMSO
  • Physical appearance
    White solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    5353431
  • Scientific context
    BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
  • Bibliography
    1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BAY 11 7082 (SIH-434), a IKK kinase inhibitor. CAS #: 19542-67-7. Molecular Formula: C10H9NO2S. Molecular Weight: 207.3 g/mol. Chemical structure of BAY 11 7082, a IKK kinase inhibitor (SIH-434). CAS # 19542-67-7. Molecular Formula: C10H9NO2S.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    BAY   7082   IKK   kinase   inhibitor  
  • Gene symbol
    IKBKE, IKBKB, CHUK, IKBKG
  • Short name
    BAY 11 7082, IKK kinase inhibitor
  • Alternative name
    BAY 11 7082, IKK phosphorylation catalyst suppressor
Gene info
  • Identity
  • Gene
  • Long gene name
    inhibitor of nuclear factor kappa B kinase subunit epsilon
  • Synonyms gene name
    • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2002-12-02
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • I kappa B kinases
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
Gene info
Gene info
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