Sunitinib malate, VEGFR, PDGFR kinase inhibitor
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Catalog numberSIH-482-25MG
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PricePlease ask
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Size25 mg
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Stock availabilitIn StockIn Stock
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CAS number557795-19-4
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DescriptionVEGFR, PDGFR kinase inhibitor
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Molecular weight398,5 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other nameN-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC22H27FN4O2
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OriginSynthetic
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Purity pourcentage≥99%
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Soluble inSoluble in DMSO (40 mg/ml)
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Physical appearanceYellow solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Reproductive toxicity (Category 1B), H360 Specific target organ toxicity-repeated exposure, Oral (Category 1), H372 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure if swallowed. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P405 Store locked up.
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PubChem number5329102
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Scientific contextSunitinib malate is a receptor tyrosine kinase inhibitor. It has been shown to target VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, c-KIT, FLT3, CSF-1R, Flk-1, and RET.
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Bibliography1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Sunitinib malate (SIH-482), a VEGFR, PDGFR kinase inhibitor. CAS #: 557795-19-4. Molecular Formula: C22H27FN4O2. Molecular Weight: 398.5 g/mol. Chemical structure of Sunitinib malate, a VEGFR, PDGFR kinase inhibitor (SIH-482). CAS # 557795-19-4. Molecular Formula: C22H27FN4O2.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.025
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPDGFRB, FLT4, KDR
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Short nameSunitinib malate, VEGFR, PDGFR kinase inhibitor
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Alternative nameSunitinib malate, VEGFR, PDGFR phosphorylation catalyst suppressor
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Gene info
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Identity
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Gene
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Long gene nameplatelet derived growth factor receptor beta
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Synonyms gene
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Synonyms gene name
- platelet-derived growth factor receptor, beta polypeptide
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefms related receptor tyrosine kinase 4
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Synonyms gene name
- fms-related tyrosine kinase 4
- fms related tyrosine kinase 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-10-25
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Entrez gene record
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Pubmed identfication
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Classification
- I-set domain containing
- Receptor tyrosine kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekinase insert domain receptor
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Synonyms gene name
- kinase insert domain receptor (a type III receptor tyrosine kinase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-07-10
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
- V-set domain containing
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VEGA ID
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Locus Specific Databases