Cell-permeable. A potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also inhibits Kit and Bcr-Abl tyrosine kinases.
Is this a salt?
Is it cell-permeable?
≥98% by TLC
DMSO (25 mg/ml) or Ethanol (10 mg/ml)
Maximum time for storage
Protect from light and air
For cells, cell lines and tissues in culture till half confluency.
PP1 for activation
PP1 to measure cellular activation