Recombinant Mouse CSNK2A1 / CK2A1 Protein (His & GST tag)

• Catalog number
  PKSM040295-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  Csnk2a1-rs4
• Activity
  The specific activity was determined to be 34 nmol/min/mg using casein as substrate.
• Sequence
  Met1-Gln391
• Fusion tag
  N-His & GST
• Accession
  Q60737
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
• Purity
  > 85 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  72.9 kDa
• AP Mol Mass
  65 kDa
• Formulation
  Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
• Background
  Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via th phosphorylation of Akt.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CSNK2A1   CK2A1   Protein   His   GST   tag  
• Gene symbol
  CSNK2A2, CSNK2A1, MGST3
• Short name
  Recombinant Mouse CSNK2A1 / CK2A1 Protein (His & GST tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse CSNK2A1 / CK2A1 Protein (histidine & GST detection labelled)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:2459
• Gene
  CSNK2A2
• Long gene name
  casein kinase 2 alpha 2
• Synonyms gene name
  • casein kinase 2, alpha prime polypeptide
• Synonyms
  • CSNK2A1
  • CK2alpha'
• Synonyms name
  • casein kinase 2 alpha'
• GenBank acession
  • M55268
• Locus
  16q21
• Discovery year
  1992-02-13
• Entrez gene record
  1459
• Pubmed identfication
  • 2174700
  • 1766873
• RefSeq identity
  • NM_001896
• VEGA ID
  OTTHUMG00000133488

Gene info

• Identity
  HGNC:2457
• Gene
  CSNK2A1
• Long gene name
  casein kinase 2 alpha 1
• Synonyms gene name
  • casein kinase 2, alpha 1 polypeptide
• Synonyms
  • Cka1
  • Cka2
• Synonyms name
  • Casein kinase II subunit alpha
• GenBank acession
  • M55265
• Locus
  20p13
• Discovery year
  1992-02-13
• Entrez gene record
  1457
• Pubmed identfication
  • 2174700
  • 1766873
• RefSeq identity
  • NM_001895
• VEGA ID
  OTTHUMG00000031636
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:7064
• Gene
  MGST3
• Long gene name
  microsomal glutathione S-transferase 3
• Synonyms
  • GST-III
• Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
• GenBank acession
  • AF026977
• Locus
  1q24.1
• Discovery year
  1997-10-16
• Entrez gene record
  4259
• Pubmed identfication
  • 9278457
• RefSeq identity
  • NM_004528
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000034627

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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