OVA conjugated Leukemia inhibitory factor(LIF)

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Description

Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
Gene

Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein. OVA is also the best characterized and the first antigen proteins used as a transgene to make transgenic mice. Many different transgenic mouse models have systemic OVA expression driven by the ubiquitously expressed b-actin promoter or tissue-specific OVA expression with insulin promoter to drive the transgene expression, for studying type I diabetes, or in different isoforms, secreted or cell-membrane associated, and more recently as inducible transgene models. These C57BL/6 mice, BALB/c mice models are well characterized, and have contributed to our understanding of immunogenicity and tolerance by the OVA model.

Gene target

OVA conjugated Leukemia inhibitory factor LIF
Gene symbol

LIF-AS1, LIF-AS2, LIF
Short name

OVA conjugated Leukemia inhibitory factor(LIF)
Technique

antibody Conjugates
Alternative name

OVA coupled Leukemia inhibitory factor(leukemia inhibitory factor)
Alternative to gene target

leukemia inhibitory factor, CDF and DIA and HILDA and MLPLI, LIF and IDBG-3968 and ENSG00000128342 and 3976, growth factor activity, Extracellular, Lif and IDBG-142317 and ENSMUSG00000034394 and 16878, LIF and IDBG-636335 and ENSBTAG00000007424 and 280840
Virus

leukemia

Identity

HGNC:6596
Gene

LIF
Long gene name

LIF interleukin 6 family cytokine
Synonyms gene name
- leukemia inhibitory factor
- LIF, interleukin 6 family cytokine
Synonyms
- CDF
- DIA
- HILDA
Synonyms name
Locus

22q12.2
Discovery year

1989-06-11
Entrez gene record

3976
Pubmed identfication
- 1714745
- 8058719
RefSeq identity
- NM_002309
Classification
- Receptor ligands
- Interleukin 6 type cytokine family
VEGA ID

OTTHUMG00000150910
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Name

Leukemia, Experimental
Concept

Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Tree numbers
- C04.557.337.372
- C04.619.531
- E05.598.500.496.500
Qualifiers

diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery