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Target antigen
IL2RB
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse IL2RB (503-539aa NLHGQDQDRGQGPILTLNTDAYLSLQELQAQDSVHLI), different from the related human sequence by sixteen amino acids, and from the related rat sequence by fourteen amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the IL2RB Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The IL2RB Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
IL2RB (INTERLEUKIN 2 RECEPTOR, BETA), also called CD122, is a protein that in humans is encoded by the IL2RB gene. The gene represents the beta subunit and is a type I membrane protein. IL2RB is mapped to 22q12.3. The IL2RB gene contains 10 exons spanning about 24.3 kb and that the gene product is encoded by exons 2-10. The IL2 receptor is present in 3 forms with respect to binding ability to IL2: high, intermediate, and low affinity forms. Analysis of mutants of the beta chain of the IL2 receptor reveals that the granulocyte and monocyte differentiation signals are triggered by different cytoplasmic domains, showing that the signaling pathways responsible for these unique developmental outcomes are separable.
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Related articles
1. Campbell, H. D., Webb, G. C., Kono, T., Taniguchi, T., Ford, J. H., Young, I. G. Assignment of the interleukin-2 receptor beta chain gene (Il-2rb) to band E on mouse chromosome 15. Genomics 12: 179-180, 1992. 2. Dai, H., Wan, N., Zhang, S., Moore, Y., Wan, F., Dai, Z. Cutting edge: programmed death-1 defines CD8+CD122+ T cells as regulatory versus memory T cells. J. Immun. 185: 803-807, 2010. 3. Yamashita, Yuki; Kojima Katsuhiko, Tsukahara Tomonori, Agawa Hideyuki, Yamada Koichiro, Amano Yuji, Kurotori Naoki, Tanaka Nobuyuki, Sugamura Kazuo, Takeshita Toshikazu (May. 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell. Sci. (England) 121 (Pt 10): 1727–38. doi:10.1242/jcs.024455.
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Gene Name
IL2RB
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Protein Name
Interleukin-2 receptor subunit beta
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Gene Full Name
interleukin 2 receptor, beta
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Synonyms
CD 122 antibody|CD122 antibody|CD122 antigen antibody|High affinity IL 2 receptor beta subunit antibody|High affinity IL 2 receptor subunit beta antibody|High affinity IL-2 receptor subunit beta antibody|High affinity IL2 receptor beta subunit antibody|High affinity IL2 receptor subunit beta antibody|IL 2 receptor antibody|IL-2 receptor subunit beta antibody|IL-2R subunit beta antibody|IL-2RB antibody|IL15RB antibody|IL2 R B antibody|IL2 RB antibody|IL2 receptor antibody|IL2RB antibody|IL2RB_HUMAN antibody|Interleukin 2 receptor beta antibody|Interleukin 2 receptor subunit beta antibody|Interleukin-2 receptor subunit beta antibody|OTTHUMP00000028799 antibody|P70 75 antibody|P70-75 antibody|P7075 antibody|p75 antibody
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Uniprot ID
P16297
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Entrez GeneID
16185
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps