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Leukadherin 1 for cell activation

Leukadherin 1 for cell activation is available 2 times from Biovision labs

2059-50 | Leukadherin-1 for cell activation size: 50 mg | 494.69 USD

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2059-10 | Leukadherin-1 for cell activation size: 10 mg | 167.92 USD

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Other name 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
Supplied with N/A
Description A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
Category Biochemicals
Molecular formula C₂₂H₁₅NO₄S₂
Is it cell-permeable? Yes
Molecular weight 421.49
Storage condition -20°C
Shipping condition gel pack
Purification ≥97% by HPLC
Peptide sequence N/A
Is this a salt? N/A
CAS number 344897-95-6
Storage instructions Protect from air and light
Maximum time for storage 24 months
Physical appearance Crystalline solid
Reconstitute instructions DMSO (10 mM)
Additional description For cells, cell lines and tissues in culture till half confluency.
Short name Leukadherin-1 for activation
Technique activation
Alternative name Leukadherin-1 to measure cellular activation
Tissue cell
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