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Leukadherin 1 for cell activation

Leukadherin 1 for cell activation is available 2 times from Biovision labs

2059-50 | Leukadherin-1 for cell activation size: 50 mg | 487.75 USD

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2059-10 | Leukadherin-1 for cell activation size: 10 mg | 165.57 USD

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Description A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
Peptide sequence N/A
CAS number 344897-95-6
Molecular weight 421.49
Category Biochemicals
Other name 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
Molecular formula C₂₂H₁₅NO₄S₂
Physical appearance Crystalline solid
Supplied with N/A
Is this a salt? N/A
Is it cell-permeable? Yes
Purification ≥97% by HPLC
Reconstitute instructions DMSO (10 mM)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 24 months
Storage instructions Protect from air and light
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetLeukadherin-1 for activation
Short name Leukadherin-1 for activation
Technique activation
Alternative name Leukadherin-1 to measure cellular activation
Tissue cell
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