RAGE, human recombinant

• Catalog number
  4271-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  Receptor for advanced glycosylation end products
• Alternative_names
  Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER
• Description
  Transmembrane receptor of the immunoglobulin super family
• Recombinant
  Yes
• Source
  Human cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Molecular Weight
  ~35 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from a 0.2 um filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.
• Reconstitution Instructions
  Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.
• Background Information
  Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
• Amino acid sequence
  Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  RAGE  
• Gene symbol
  AGER, MOK
• Short name
  RAGE, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  RAGE, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:320
• Gene
  AGER
• Long gene name
  advanced glycosylation end-product specific receptor
• Synonyms
  • RAGE
  • SCARJ1
  • sRAGE
• Synonyms name
  • receptor for advanced glycation end-products
• GenBank acession
  • M91211
• Locus
  6p21.32
• Discovery year
  1994-10-17
• Entrez gene record
  177
• Pubmed identfication
  • 7713518
• RefSeq identity
  • NM_001136
• Classification
  • Scavenger receptors
  • C2-set domain containing
• VEGA ID
  OTTHUMG00000031120

Gene info

• Identity
  HGNC:9833
• Gene
  MOK
• Long gene name
  MOK protein kinase
• Synonyms gene
  • RAGE
• Synonyms gene name
  • renal tumor antigen
• Synonyms
  • RAGE1
  • STK30
• GenBank acession
  • AB022694
• Locus
  14q32.31
• Discovery year
  1995-05-10
• Entrez gene record
  5891
• Pubmed identfication
  • 8781117
  • 10421840
• VEGA ID
  OTTHUMG00000164896

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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