Human CellExp™ LEFTY-I, Human Recombinant
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Catalog number4873-50
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PricePlease ask
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Size50 ug
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SynonymsHuman Recombinant LEFTY-I
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Alternative_namesLeft-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B
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DescriptionPlays a role in left-right asymmetry determination of organ systems during development
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RecombinantYes
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SourceHuman 293 cells
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Biological activityThe specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse Chondrogenic cell line).
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ResultsTypically 10 to 40 ng/mL ED50.
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Molecular Weight38 kDa
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Storage Temp-20°C
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ShippingBlue ice
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionLyophilized in 10 mM Tris-HCl, pH 7.4, 50 mM NaCl, 0.5% CHAPS.
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Reconstitution InstructionsReconstitute in sterile water.
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Background InformationBioVision’s LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media. Lefty proteins function as an antagonist of the Nodal Signaling pathway. Proper functioning of Lefty is crucial to the proper development of the heart, lungs, spleen, and liver.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolFABP6, TANK, FABP2, PSMB2, CPLX1, MDFI, B3GAT3, IGLVI-38, SNAR-I
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Short nameCellExp™ LEFTY-I, Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ LEFTY-I, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 6
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Synonyms gene name
- fatty acid binding protein 6, ileal
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTRAF family member associated NFKB activator
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Synonyms gene
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Synonyms gene name
- TRAF family member-associated NFKB activator
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-06-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 2
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Synonyms gene name
- fatty acid binding protein 2, intestinal
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproteasome 20S subunit beta 2
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Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 2
- proteasome subunit beta 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-05-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proteasome
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecomplexin 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-09
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMyoD family inhibitor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-10-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebeta-1,3-glucuronyltransferase 3
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Synonyms gene name
- beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-01-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Beta-1,3-glucuronyltransferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable (I)-38 (pseudogene)
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Synonyms gene name
- immunoglobulin lambda variable (I)-38
- immunoglobulin lambda variable (I)-38 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall NF90 (ILF3) associated RNA I
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Synonyms gene name
- small ILF3/NF90-associated RNA I
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2008-07-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small NF90 (ILF3) associated RNAs
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
