BI-847325

Alternative_name

(Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
Description

BI-847325 is an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI-847325 was demonstrated in enzymatic and cellular assays.
CAS Number

1207293-36-4
Structure Available

Yes
Molecular Formula

C₂₉H₂₈N₄O₂
Molecular Weight

464.57
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

an ATP-competitive dual inhibitor of MEK and Aurora kinases.
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

54577344
PubChem CID Link
SMILES

CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN(C)C)C(=O)N2
InChi

InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30,34)(H,32,35)/b28-27-
InChi Key

FLBNLJLONKAPLR-DQSJHHFOSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1664
Gene

SCARB1
Long gene name

scavenger receptor class B member 1
Synonyms gene
- CD36L1
Synonyms gene name
- CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
- scavenger receptor class B, member 1
Synonyms
- SRB1
- CLA-1
- CLA1
- SR-BI
GenBank acession
- Z22555
Locus

12q24.31
Discovery year

1994-09-06
Entrez gene record

949
Pubmed identfication
- 7689561
RefSeq identity
- NM_005505
Classification
- Scavenger receptors
VEGA ID

OTTHUMG00000168544